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At autopsy, the present case exhibited neuropathological findings compatible with those of corticobasal degeneration, including atrophy of the frontal and temporal lobes, neuronal loss and gliosis in the cortical and subcortical regions, and presence of cortical ballooned neurons and astrocytic plaques. Moreover, many senile plaques were found in the cerebral cortex. There were also clusters of A\u03b2\u2010positive granules associated with astrocytic cytoplasm and processes in the subiculum and entorhinal cortex. In the entorhinal cortex, the A\u03b2\u2010positive granules were occasionally co\u2010localized with phosphorylated tau\u2010positive fibrillary structures in the astrocytic cytoplasm. To our knowledge, this is the first demonstration of co\u2010localization of A\u03b2 and phosphorylated tau in astrocytes. This phenomenon implies that phagocytosis of A\u03b2 coincides with production of phosphorylated tau in the same reactive astrocytes.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00635.x","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:49:48Z","timestamp":1138042188000},"page":"66-71","source":"Crossref","is-referenced-by-count":5,"title":["Co\u2010localization of \u03b2\u2010peptide and phosphorylated tau in astrocytes in a patient with corticobasal 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