{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:52:25Z","timestamp":1790664745863,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>The microtubule\u2010associated protein tau aggregates into filaments in the form of neurofibrillary tangles, neuropil threads and argyrophilic grains in neurons, in the form of variable astrocytic tangles in astrocytes and in the form of coiled bodies and argyrophilic threads in oligodendrocytes. These tau filaments may be classified into two types, straight filaments or tubules with 9\u201318\u2003nm diameters and \u201ctwisted ribbons\u201d composed of two parallel aligned components. In the same disease, the fine structure of tau filaments in glial cells roughly resembles that in neurons. In sporadic tauopathies, individual tau filaments show characteristic sizes, shapes and arrangements, and therefore contribute to neuropathologic differential diagnosis. In frontotemporal dementias caused by tau gene mutations, variable filamentous profiles were observed in association with mutation sites and insoluble tau isoforms, including straight filaments or tubules, paired helical filament\u2010like filaments, and twisted ribbons. Pre\u2010embedding immunoelectron microscopic studies were carried out using anti\u20103\u2010repeat tau and anti\u20104\u2010repeat tau specific antibodies, RD3 and RD4. Straight tubules in neuronal and astrocytic Pick bodies were immunolabeled by the anti\u20103\u2010repeat tau antibody. The anti\u20104\u2010repeat tau antibody recognized abnormal tubules comprising neurofibrillary tangles, coiled bodies and argyrophilic threads in progressive supranuclear palsy (PSP) and corticobasal degeneration. In the pre\u2010embedding immunoelectron microscopic study using the phosphorylated tau AT8 antibody, tuft\u2010shaped astrocytes of PSP were found to be composed of bundles of abnormal tubules in processes and perikarya of protoplasmic astrocytes. In this study, the 3\u2010repeat tau or 4\u2010repeat tau epitope was detected <jats:italic>in situ<\/jats:italic> at the ultrastructural level in abnormal tubules in representative pathological lesions in Pick\u2019s disease, PSP and corticobasal degeneration.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00669.x","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T09:21:05Z","timestamp":1159348865000},"page":"475-483","source":"Crossref","is-referenced-by-count":102,"title":["Ultrastructural characteristics of tau filaments in tauopathies: Immuno\u2010electron microscopic demonstration of tau filaments in tauopathies"],"prefix":"10.1111","volume":"26","author":[{"given":"Kunimasa","family":"Arima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00549.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511526886.012"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511526886.013"},{"key":"e_1_2_6_5_2","first-page":"368","article-title":"Ultrastructural characteristics of tauopathy.","volume":"11","author":"Arima K","year":"1999","journal-title":"Brain Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1787"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.6.547"},{"key":"e_1_2_6_8_2","first-page":"1052","article-title":"Immunocytochemical characterization of glial fibrillary tangles in Alzheimer\u2019s disease brain","volume":"146","author":"Nishimura M","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296498"},{"key":"e_1_2_6_10_2","first-page":"147","article-title":"A study of tau\u2010positive, argyrophilic glial structures (Glial fibrillary tangle) (I) Classification and specificity for cytoskeletal disorders.","volume":"40","author":"Ikeda K","year":"1996","journal-title":"Shinkei Kenkyuuno Shinpo (Adv Neurol Sci)"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1989.tb01146.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307644"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.6.2288"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199701000-00008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90072-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296783"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050762"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050652"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.1996.tb00157.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90010-8"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2006.00669.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2006.00669.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:43:16Z","timestamp":1696909396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2006.00669.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,27]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1440-1789.2006.00669.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2006.00669.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,27]]}}}