{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:09:12Z","timestamp":1780369752268,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T00:00:00Z","timestamp":1148256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>We report clinical, neuroradiologic features, and neuropathologic findings of a 76\u2010year\u2010old man with coexistent Pick\u2019s disease and progressive supranuclear palsy. The patient presented with loss of recent memory, abnormal behavior and change in personality at the age of 60. The symptoms were progressive. Three years later, repetitive or compulsive behavior became prominent. About 9\u2003years after onset, he had difficulty moving and became bed\u2010ridden because of a fracture of his left leg. His condition gradually deteriorated and he developed mutism and became vegetative. The patient died from pneumonia 16\u2003years after the onset of symptoms. Serial MRI scans showed progressive cortex atrophy, especially in the bilateral frontal and temporal lobes. Macroscopic inspection showed severe atrophy of the whole brain, including cerebrum, brainstem and cerebellum. Microscopic observations showed extensive superficial spongiosis and severe neuronal loss with gliosis in the second and third cortical layers in the frontal, temporal and parietal cortex. There were Pick cells and argyrophilic Pick bodies, which were tau\u2010 and ubiquitin\u2010positive in neurons of layers II\u2013III of the above\u2010mentioned cortex. Numerous argyrophilic Pick bodies were observed in the hippocampus, especially in the dentate fascia. In addition, moderate to severe loss of neurons was found with gliosis and a lot of Gallyas\/tau\u2010positive globus neurofibrillary tangles in the caudate nucleus, globus pallidus, thalamus, substantia nigra, locus coeruleus and dentate nucleus. Numerous thorned\u2010astrocytes and coiled bodies but no\u2010tuft shaped astrocytes were noted in the basal ganglion, brainstem and cerebellar white matter. In conclusion, these histopathological features were compatible with classical Pick\u2019s disease and coexistence with progressive supranuclear palsy without tuft\u2010shaped astrocytes.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00671.x","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T10:02:49Z","timestamp":1148292169000},"page":"222-230","source":"Crossref","is-referenced-by-count":9,"title":["Pick\u2019s disease with Pick bodies combined with progressive supranuclear palsy without tuft\u2010shaped astrocytes: A clinical, neuroradiologic and pathological study of an autopsied 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