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It is thought that drinking water containing low levels of calcium (Ca) and magnesium (Mg), and high levels of aluminum and of a plant excitatory neurotoxin are involved in the pathogenesis of these diseases. The present experiment was performed in rats that were exposed to low Ca and\/or Mg intake over two generations, thus simulating the conditions of human life on Guam, where several generations live continuously in the same environment. Significant loss of dopaminergic neurons was identified exclusively in the substantia nigra in 1\u2010year\u2010old rats that had been exposed continuously to low Mg intake (one\u2010fifth of the normal level) over generations. The present study suggests that low Mg intake over generations may be involved in the pathogenesis of substantia nigra degeneration in humans.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00672.x","type":"journal-article","created":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T10:23:07Z","timestamp":1144664587000},"page":"115-128","source":"Crossref","is-referenced-by-count":71,"title":["Magnesium deficiency over generations in rats with special references to the pathogenesis of the parkinsonism\u2013dementia complex and amyotrophic lateral sclerosis of 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