{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:02:15Z","timestamp":1790917335305,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T00:00:00Z","timestamp":1148256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>We report a case of pineal parenchymal tumor in a 33\u2010year\u2010old man incidentally detected by radiological examination. The MRI showed an unhomogeneously enhanced, small tumor (approximately 1\u2003cm in size) in the pineal region. A tumor specimen was obtained at endoscopic biopsy. Routine histology showed a highly cellular tumor characterized by a predominance of small cells showing high nuclear\u2003:\u2003cytoplasmic ratio and moderate nuclear atypia, pleomorphism including giant cells and an absence of pineocytomatous rosettes. Mitotic figures were rare (approximately 1 per 10 high\u2010power fields). Tumor necrosis was not evident. Immunohistochemically, the neoplastic cells showed positivity for neural markers (neurofilament protein, synaptophysin) and pinealocyte\u2010associated antibodies (PP1, PP5, PP6), but not for glial fibrillary acidic protein or S\u2010100. The MIB\u20101 labeling index was relatively high (6.3%). Ultrastructurally, there was some evidence of pinealocytic differentiation, such as vesicle\u2010crowned rodlets (synaptic ribbons) and paired twisted filaments in neoplastic cells. Thus, the tumor was confirmed as a pineal parenchymal tumor of intermediate differentiation by histology, immunohistochemistry and electron microscopy. This case indicates that marked cytologic pleomorphism can occur in pineal parenchymal tumors of intermediate differentiation.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00676.x","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T10:02:49Z","timestamp":1148292169000},"page":"212-217","source":"Crossref","is-referenced-by-count":20,"title":["Pineal parenchymal tumor of intermediate differentiation with cytologic pleomorphism"],"prefix":"10.1111","volume":"26","author":[{"given":"Atsushi","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,22]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"115","volume-title":"Pathology and Genetics of Tumours of the Nervous System","author":"Mena H","year":"2000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389497"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00242.x"},{"key":"e_1_2_5_5_2","first-page":"621","article-title":"Localization of S\u2010100 protein and glial fibrillary acidic protein\u2010related antigen in pleomorphic adenoma of the salivary glands","volume":"46","author":"Nakazato Y","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_5_6_2","first-page":"1055","article-title":"Studies on the immunohistochemical localization of S\u2010100 and glial fibrillary acidic proteins in the rat nervous system and in human brain tumors","volume":"32","author":"Yamaguchi H","year":"1980","journal-title":"No To Shinkei"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0919-6544.2001.00423.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2002.00430.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310377"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913129409016276"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690471"},{"key":"e_1_2_5_12_2","first-page":"265","article-title":"Paired twisted filaments in human pinealocytes","volume":"41","author":"Hasegawa A","year":"1991","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90110-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478904"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200207000-00006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000129479.70696.D2"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930801)72:3<870::AID-CNCR2820720336>3.0.CO;2-X"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEON.0000041885.09226.2d"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688690120072441"},{"key":"e_1_2_5_20_2","volume-title":"Neuropathology: a Reference Text of CNS Pathology","author":"Ellison D","year":"2004"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2006.00676.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2006.00676.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T03:05:48Z","timestamp":1697252748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2006.00676.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,22]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1440-1789.2006.00676.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2006.00676.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,22]]}}}