{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:14:40Z","timestamp":1770822880051,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T00:00:00Z","timestamp":1164326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Solitary fibrous tumor (SFT), a benign neoplasm arising in mesenchymal structures, was initially described in the pleura but subsequently has also been documented in other locations. It is uncommon in the orbit, where it closely resembles other benign spindle\u2010shaped mesenchymal tumors of this area such as schwannoma, meningioma or hemangiopericytoma. We present a case of orbital SFT in a 34\u2010year\u2010old woman. The radiological study showed the presence of an enhanced uptake lesion measuring 2\u2003cm in major diameter. The histopathological evaluation revealed alternating cellular and hypocellular areas with spindle\u2010shaped cells. The cellular organization displayed a broad variety of irregular morphological patterns. The neoplastic cells were intensely positive for CD34 and vimentin, while S100, epithelial membrane antigen (EMA), Caldesmon, Calretinin and WT\u20101 proved negative. The pericellular matrix exhibited strong positivity for CD44 and collagen IV. Scarce mitotic figures, a Ki\u201067 nuclear labeling index of &lt;5%, and focal expression of p53 were also observed. Measurement of DNA content revealed a DNA index of 1, indicating a diploid peak in 95% of the tumor cells. A normal 46,XX karyotype was present. No <jats:italic>TP53<\/jats:italic> (exons 5\u20138) mutations or <jats:italic>MDM2<\/jats:italic> and <jats:italic>CDK4<\/jats:italic> amplifications were observed. No <jats:italic>p14<\/jats:italic><jats:sup><jats:italic>ARF<\/jats:italic><\/jats:sup>, <jats:italic>p15<\/jats:italic><jats:sup><jats:italic>INK4B<\/jats:italic><\/jats:sup> and <jats:italic>p16<\/jats:italic><jats:sup><jats:italic>INK4A<\/jats:italic><\/jats:sup> deletions or hypermethylation were observed in this benign tumor. Following surgical resection and radiotherapy, the patient showed no tumor relapse after one year of follow\u2010up.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00726.x","type":"journal-article","created":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T09:29:14Z","timestamp":1164360554000},"page":"557-563","source":"Crossref","is-referenced-by-count":26,"title":["Solitary fibrous tumor of the orbit: Morphological, cytogenetic and molecular features"],"prefix":"10.1111","volume":"26","author":[{"given":"Miguel","family":"Cerd\u00e1\u2010Nicol\u00e1s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concha","family":"L\u00f3pez\u2010Gines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Gil\u2010Benso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Benito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Ruiz\u2010Saur\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sanchos\u2010Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Roldan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Talamantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Barber\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,24]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"385","article-title":"Primary neoplasm of the pleura: a report of five cases","volume":"11","author":"Klemperer P","year":"1931","journal-title":"Arch Pathol"},{"key":"e_1_2_5_3_2","volume-title":"Diagnostic Soft Tissue Pathology.","author":"Miettinen M","year":"2003"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.2.217"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68109-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb01499.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290407.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.5858\/2003-127-0432-SFTITC","article-title":"Solitary fibrous tumors in the central nervous system. 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