{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:44:55Z","timestamp":1789987495999,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Lewy bodies (LB) usually extend from the brainstem to the cerebrum in patients with Parkinson\u2019s disease. However, whether the patterns of progression of LB and neuronal loss in Parkinson\u2019s disease are identical to those in other Lewy body diseases (LBD) remains unclear. In addition, pathological data on the autonomic nervous system involvement in LBD are limited. We present here the clinicopathological characteristics of two autopsy cases with both Alzheimer\u2019s disease and dementia with Lewy bodies (DLB), possibly diagnosed as having Lewy body variant of Alzheimer\u2019s disease (LBV\/AD). Our patients presented clinically with dementia without parkinsonism. Histopathologically, phosphorylated \u03b1\u2010synuclein\u2010positive LB and Lewy neurites were abundant in the limbic system, especially in the amygdala, and to a lesser degree, in the neocortex, including the primary motor cortex. The amygdala was also most severely affected by neuronal loss, and the other limbic areas and neocortex were affected to a lesser degree. Despite the existence of a small number of LB and many Lewy neurites, neurons in the brainstem nuclei were relatively well preserved. The Braak stages of concurrent neurofibrillary changes and senile plaques were stage V and C, respectively, in both cases. Tyrosine hydroxylase\u2010positive nerve fibers were relatively well spared in one case examined compared with Parkinson\u2019s disease cases. Furthermore, many Lewy neurites immunopositive for phosphorylated \u03b1\u2010synuclein were found in the nerve fascicles of the epicardium in one case examined and in Parkinson\u2019s disease cases to a lesser degree. These findings suggest that: (i) in at least some LBV\/AD cases, the amygdala develops neuronal loss and Lewy\u2010related pathology prior to the brainstem nuclei; and (ii) the depletion of nerves in the heart tissue of LBV\/AD is not necessarily complete despite the development of Lewy\u2010related pathology.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2006.00736.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T11:13:50Z","timestamp":1169723630000},"page":"21-35","source":"Crossref","is-referenced-by-count":23,"title":["Lewy body variant of Alzheimer\u2019s disease or cerebral type Lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem"],"prefix":"10.1111","volume":"27","author":[{"given":"Osamu","family":"Yokota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ujike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishi","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafuyu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"188","volume-title":"Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders.","author":"Ince PG","year":"2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01072.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.1.1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.5.413"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0725-y"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"issue":"4","key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1016\/S0197-4580(97)00057-2","article-title":"Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. 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