{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:42Z","timestamp":1761823002700},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T00:00:00Z","timestamp":1184803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>We report the case of a multifocal dysembryoplastic neuroepithelial tumor (DNT) in a 7\u2010year\u2010old girl with local tumor regrowth 6 years later. The tumor was localized in the right parietal lobe extending from the cortex into the periventricular white matter. After subtotal resection of a histopathologically confirmed DNT we observed unexpected tumor progression in long\u2010term follow\u2010up. Therefore, a second surgery was performed when the patient was 14\u2003years of age. In neuropathological examination of the second specimen the tumor showed an increased cellularity and pleomorphism, microvascular proliferations, an elevated proliferative activity (MIB1\u2010index focally up to 10%) and cellular atypia not typical for WHO grade I DNT. Furthermore, MRI studies showed additional supratentorial and infratentorial lesions which remained stable over years and are also well consistent with DNTs. Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2007.00780.x","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T17:12:11Z","timestamp":1184865131000},"page":"383-389","source":"Crossref","is-referenced-by-count":23,"title":["Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth"],"prefix":"10.1111","volume":"27","author":[{"given":"Jens","family":"Schittenhelm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Mittelbronn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Truebenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd E.","family":"Will","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Meyermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi","family":"Beschorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198811000-00002"},{"key":"e_1_2_6_3_2","first-page":"103","volume-title":"Pathology and Genetics of Tumours of the Nervous System","author":"Daumas\u2010Duport C","year":"2000"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006193018140"},{"key":"e_1_2_6_5_2","first-page":"47","article-title":"Dysembryoplastic neuroepithelial tumor: a clinicopathologic and immunohistochemical study of 11 tumors including MIB1 immunoreactivity","volume":"15","author":"Prayson RA","year":"1996","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_6_2","first-page":"223","article-title":"Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy","volume":"23","author":"Vogelgesang S","year":"2004","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228581"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.22.5.g02se051177"},{"key":"e_1_2_6_9_2","first-page":"419","article-title":"Dysembryoplastic neuroepithelial tumors: MR and CT evaluation","volume":"17","author":"Ostertun B","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.1.97"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130495.69512.6F"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00208-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.3.0487"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2005.00680.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296517"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199406000-00004"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/0268869998540629","article-title":"Dsyembryoplastic neuroepithelial tumour with discrete bilateral multifocality: further evidence for a germinal origin","volume":"13","author":"Whittle IR","year":"1999","journal-title":"Br J Neurosurg"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000115266.16119.3A"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.92.4.0722"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(03)00070-4"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309345"},{"key":"e_1_2_6_22_2","volume-title":"Tumors of the Central Nervous System. 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