{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:44:15Z","timestamp":1791902655153,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T00:00:00Z","timestamp":1190073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Histological analysis has limited value to predict biological behavior of meningiomas. We investigated the utility of cell proliferative indicator in the evaluation of histologically benign meningiomas. We selected 25 benign non\u2010recurrent meningiomas, 15 benign recurrent meningiomas after complete surgical resection, 30 atypical meningiomas, and 15 anaplastic meningiomas out of 384 cases studied. MIB\u20101 Labeling Index was evaluated by two methods: Highest Labeling Index (HLI) and Random Labeling Index (RLI). There was no dependable histological parameter to predict recurrence among benign\u2010looking meningiomas. HLI had significant difference when compared with RLI in all categories. The mean MIB\u20101 HLI values\u2003\u00b1\u2003SD were 3.47\u2003\u00b1\u20032.0% for benign meningiomas, 5.08\u2003\u00b1\u20034.0% for atypical meningiomas and 11.66\u2003\u00b1\u20037.06% for anaplastic meningiomas. In comparison, the mean MIB\u20101 HLI of benign non\u2010recurrent meningiomas were 2.66\u2003\u00b1\u20031.7% and with recurrence were 4.21\u2003\u00b1\u20032.78% (<jats:italic>P<\/jats:italic>\u2003= 0.0339). Using receiver operating characteristic, it was seen that neoplasm recurred with the MIB\u20101 HLI of &gt;\u20032.6 having the sensitivity of 64.6% and specificity of 68% among benign (grade I) meningiomas. MIB\u20101 positive tumor cells were maximally aggregated at the periphery of excised specimen. MIB\u20101 HLI, integrated with standard histopathology can provide better information about the disease biological nature in benign meningiomas.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2007.00801.x","type":"journal-article","created":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T13:11:00Z","timestamp":1190380260000},"page":"407-412","source":"Crossref","is-referenced-by-count":37,"title":["MIB\u20101 immunolabeling: A valuable marker in prediction of benign recurring meningiomas"],"prefix":"10.1111","volume":"27","author":[{"given":"Mahesha","family":"Vankalakunti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Vasishta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishan Das","family":"Radotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender Kumar","family":"Khosla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"449","volume-title":"Pathology of Tumours of the Nervous System","author":"Russell DS","year":"1989"},{"key":"e_1_2_6_3_2","first-page":"176","volume-title":"Pathology and Genetics. Tumors of the Nervous System: WHO Classification of Tumors","author":"Louis DN","year":"2000"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5858\/1999-123-0793-HFAMLI","article-title":"Histopathologic Features and Ki\u201067 Labeling Indices in Recurrent and Nonrecurrent Meningiomas","volume":"123","author":"Abramovich CM","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(86)90081-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.58.1.0051"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198612000-00002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90107-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01411126"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10351"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941215)74:12<3176::AID-CNCR2820741217>3.0.CO;2-N"},{"key":"e_1_2_6_12_2","first-page":"179","article-title":"Recurrent meningiomas\u2010 the immunohistochemical analysis of angiogenesis and cellular proliferation","volume":"37","author":"Izycka\u2010Swieszewska E","year":"1999","journal-title":"Folia Neuropathol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90224-6"},{"key":"e_1_2_6_14_2","first-page":"25","article-title":"Quantification and topographical description of Ki\u201067 antibody labelling during the cell cycle of normal fibroblastic (MRC\u20105) and mammary tumor cell lines (MCF\u20107)","volume":"1","author":"Guillaud P","year":"1989","journal-title":"Anal Cell Pathol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1242\/jcs.92.4.531","article-title":"Ki\u201067 detects a nuclear matrix\u2010associated proliferation\u2010related antigen. IL\u2010Localization in mitotic cells and association with chromosomes","volume":"92","author":"Verheijen R","year":"1989","journal-title":"J Cell Sci"},{"key":"e_1_2_6_16_2","first-page":"336","article-title":"Diagnostic Validity of the Ki\u201067 labeling index using the Mib\u20101 monoclonal aantibody in the grading of meningiomas","volume":"51","author":"Devaprasath A","year":"2003","journal-title":"Neurol India"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80050-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200103000-00027"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050458"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00006"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2007.00801.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2007.00801.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:23:33Z","timestamp":1697307813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2007.00801.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,18]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1440-1789.2007.00801.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2007.00801.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,18]]}}}