{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T02:14:10Z","timestamp":1712024050252},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T00:00:00Z","timestamp":1317859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Progressive nonfluent aphasia (PNFA) is a clinical subtype of frontotemporal lobar degeneration (FTLD). FTLD with tau accumulation (FTLD\u2010tau) and FTLD with TDP\u201043 accumulation (FTLD\u2010TDP) both cause PNFA. We reviewed clinical records of 29 FTLD\u2010TDP cases in the brain archive of our institute and found only one case of PNFA. The patient was an 81\u2010year\u2010old male at death. There was no family history of dementia or aphasia. He presented with slow, labored and nonfluent speech at age 75. Behavioral abnormality and movement disorders were absent. MRI at age 76 demonstrated atrophy of the perisylvian regions, including the inferior frontal gyrus, insular gyrus and superior temporal gyrus. The atrophy was more severe in the left hemisphere than the right. On post mortem examinations, neuronal loss was evident in these regions as well as in the substantia nigra. There were abundant TDP\u201043\u2010immunoreactive neuronal cytoplasmic inclusions and round or irregular\u2010shaped structures in the affected cerebral cortices. A few dystrophic neurites and neuronal intranuclear inclusions were also seen. FTLD\u2010TDP showing PNFA seems to be rare but does exist in Japan, similar to that in other countries.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2011.01253.x","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T03:02:32Z","timestamp":1317956552000},"page":"272-279","source":"Crossref","is-referenced-by-count":2,"title":["Progressive nonfluent aphasia: A rare clinical subtype of FTLD\u2010TDP in 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