{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T15:48:15Z","timestamp":1773589695333,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>The occurrence of Ewing sarcoma\u2010peripheral primitive neuroectodermal tumor as a primary intracranial tumor is very rare, with only 29 cases reported in the literature, 19 of which have included molecular studies. We present the clinical, radiologic and pathologic findings of an intracranial Ewing sarcoma in a 22\u2010year\u2010old woman arising from the dura over the right frontal convexity. The patient underwent craniotomy with gross total excision of the tumor. The tumor showed atypical histology and the diagnosis was confirmed by detection of a rearrangement of the <jats:italic>EWSR1<\/jats:italic> gene by fluorescent in situ hybridization and identification of the diagnostic t(11;22)(q24;q12) translocation by reverse transcription\u2010polymerase chain reaction. Additional features were detected in this tumor that are known to be associated with an unfavorable prognosis, including loss of p16 expression and gains of chromosomes 1q and 12. The patient experienced the most rapid downhill course reported to date for intracranial Ewing sarcoma, developing multiple extracranial metastases at 2 months and dying 6 months after the initial operation.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2011.01258.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T13:00:33Z","timestamp":1318942833000},"page":"293-300","source":"Crossref","is-referenced-by-count":27,"title":["Primary intracranial Ewing sarcoma with an unusually aggressive course: A case report and review of the literature"],"prefix":"10.1111","volume":"32","author":[{"given":"Jantima","family":"Tanboon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunpot","family":"Sitthinamsuwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewajetsada","family":"Paruang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Marrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Thorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197310)32:4<890::AID-CNCR2820320421>3.0.CO;2-O"},{"key":"e_1_2_6_3_2","first-page":"945","volume-title":"Weiss & Goldblum: Enzinger and Weiss's Soft Tissue Tumors","author":"Weiss SW","year":"2008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000167056.13614.62"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0842-7"},{"key":"e_1_2_6_6_2","first-page":"298","volume-title":"Pathology and Genetics of Tumours of Soft Tissue and Bone","author":"Ushigome S","year":"2002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2003.09.007"},{"key":"e_1_2_6_8_2","first-page":"141","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"McLendon RE","year":"2007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/107710496175949"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02739968"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006432919281"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880585"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01961.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20430"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000210215.73374.EE"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.02.011"},{"key":"e_1_2_6_17_2","first-page":"580","article-title":"Central nervous system extraosseous Ewing sarcoma: radiologic manifestations of this newly defined pathologic entity","volume":"27","author":"Pekala JS","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e3180375541"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3171\/PED-07\/11\/411"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-008-1601-2"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.57215"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181f82569"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.5414\/NPP29372"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2010.01196.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-002-0013-1"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-009-0104-6"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.8-2-174"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.5858\/2010-0594-RAIR.1","article-title":"Molecular diagnostics of soft tissue tumors","volume":"135","author":"Bridge JA","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25840"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22821"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10212"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199903)32:3<186::AID-MPO5>3.0.CO;2-D"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.6.1809"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1248"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.4.1245"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.3585"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.5845"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000815)89:4<793::AID-CNCR11>3.0.CO;2-M"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690190"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000815)89:4<783::AID-CNCR10>3.0.CO;2-Q"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199704000-00008"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600332"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2011.01258.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2011.01258.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T22:39:28Z","timestamp":1698705568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2011.01258.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,18]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1440-1789.2011.01258.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2011.01258.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,18]]}}}