{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:44:45Z","timestamp":1778546685271,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T00:00:00Z","timestamp":1321228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Parkinson's disease is now recognized as a major form of \u03b1\u2010synucleinopathy involving both the central and peripheral nervous systems. However, no research has focused on the posterior pituitary lobe (PPL), despite the fact that this organ also plays an important role in systemic homeostasis. In the present study, we aimed to distinguish phosphorylated \u03b1\u2010synuclein (p\u03b1Syn)\u2010positive deposits in the PPL, as is observed in Lewy body\u2010 and non\u2010Lewy body\u2010related disorders. P\u03b1Syn deposits were immunohistochemically analyzed using formalin\u2010fixed, paraffin\u2010embedded PPL specimens obtained from 60 autopsy cases. Among the cases with Lewy body\u2010related disorders, PPL p\u03b1Syn deposits were observed in almost all cases of Parkinson's disease (22\/23), and in one case of dementia with Lewy bodies (1\/1). On the other hand, only 3\/36 cases of non\u2010Lewy body\u2010related disorders had p\u03b1Syn immunoreactivity in the PPL. The present study confirms the presence of p\u03b1Syn\u2010positive deposits, as demonstrated by high specificity (97.1%) and sensitivity (88.5%), in both Parkinson's disease and dementia with Lewy bodies, suggesting that this finding can be a useful hallmark of Lewy body\u2010related disorders.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2011.01273.x","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T14:57:15Z","timestamp":1321369035000},"page":"385-389","source":"Crossref","is-referenced-by-count":17,"title":["Phosphorylated \u03b1\u2010synuclein immunoreactivity in the posterior pituitary lobe"],"prefix":"10.1111","volume":"32","author":[{"given":"Taku","family":"Homma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.67"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93275-R"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.042"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000113469"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.11.012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0193-x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0345-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm302"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb748"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.1.14"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.1.84"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1980.tb03130.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.2.3659370"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq091"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2011.01273.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2011.01273.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:37:50Z","timestamp":1698673070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2011.01273.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,14]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1440-1789.2011.01273.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2011.01273.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,14]]}}}