{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:06:48Z","timestamp":1787393208330,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome. The hallmark of NF2 is bilateral vestibular schwannoma. In addition, glioma is one of the diagnostic criteria of NF2. In this retrospective study the clinical presentation and histopathological features of 12 spinal gliomas from NF2 patients were assessed. Ten tumors were previously diagnosed as ependymomas and two as astrocytomas. However, upon re\u2010evaluation both astrocytomas expressed epithelial membrane antigen in a dot\u2010like fashion and in one case it was possible to perform electron microscopy revealing junctional complexes and cilia typical for ependymoma. The findings suggest that NF2\u2010associated spinal gliomas are ependymomas. Based on the fact that NF2\u2010associated gliomas are almost exclusively spinal and that no <jats:italic>NF2<\/jats:italic> mutations have been found in sporadic cerebral gliomas, we suggest that \u201cglioma\u201d in the current diagnostic criteria for NF2 should be specified as \u201cspinal ependymoma\u201d.<\/jats:p>","DOI":"10.1111\/j.1440-1789.2012.01306.x","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T07:48:26Z","timestamp":1331106506000},"page":"611-616","source":"Crossref","is-referenced-by-count":30,"title":["Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2\u2010associated gliomas to be spinal ependymomas"],"prefix":"10.1111","volume":"32","author":[{"given":"Christian","family":"Hagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat O.","family":"Stemmer\u2010Rachamimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Bornemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Huson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Gareth","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Plotkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Matthies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Kluwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor\u2010Felix","family":"Mautner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"603","article-title":"A clinical study of type 2 neurofibromatosis","volume":"84","author":"Evans DG","year":"1992","journal-title":"Q J Med"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ac9a27"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0535-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199601000-00009"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.4.7676998"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.2.r01fe40434"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2007-027"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000255426.08926.95"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00591-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199510000-00022"},{"key":"e_1_2_6_12_2","first-page":"45","article-title":"Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas","volume":"54","author":"Rubio MP","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02482172"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1054603"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1335605"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000158397.65190.9f"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294370"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913129709023248"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1789.2012.01306.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1789.2012.01306.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T19:17:14Z","timestamp":1698693434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1789.2012.01306.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,7]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1440-1789.2012.01306.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1789.2012.01306.x","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,7]]}}}