{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:58:19Z","timestamp":1776531499314,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:00:00Z","timestamp":1103673600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p><jats:bold>Background:\u2003<\/jats:bold> Sleep disturbances, in particular restless legs or limb movements, during the night are often reported by uremic patients. However, polysomnography (PSG) studies have never been carried out to confirm the actual occurrence of these disorders and the association with other objective and self\u2010reported sleep\u2013wake data.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Forty\u2010eight participants were subjected to a 2\u2010day PSG. These data on sleep including periodic limb movements, which are associated with restless legs, were correlated with clinical observations, quality of sleep\u2013wake and life questionnaires, and with biochemical and neurographical measures.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Restless legs syndrome (RLS) was observed in 58.3% of the patients and periodic limb movement disorder (PLMD) occurred in 70.8% of the patients. PLMD was revealed polysomnographically in almost 90% of the RLS patients. Patients with both PLMD and RLS had significantly poorer sleep quality than those with neither disorder or with PLMD alone, both in terms of self\u2010reported data and the PSG. Quality of life was significantly worse in patients with RLS and PLMD compared to those patients with neither disorder. PLMD patients also tended to have a lower quality of life. All other metabolic \u200ameasures \u200aand \u200athe \u200aresults \u200aof \u200aa \u200anerve \u200aconduction \u200atest \u200awere \u200anot \u200acorrelated \u200awith \u200aRLS \u200aand\/or PLMD.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> There was a high prevalence of severe RLS and PLMD in the present sample of uraemia patients. Nearly all RLS patients had severe PLMD. RLS (in combination with PLMD) in dialysis is associated with poor sleep quality, insomnia complaints, depression and emotional distress. Our results suggest that PLMD per se is also clinically relevant.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2004.00330.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T10:57:54Z","timestamp":1103713074000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Periodic limb movement disorder and restless legs syndrome in dialysis patients"],"prefix":"10.1111","volume":"9","author":[{"given":"ROSELYNE M","family":"RIJSMAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AL W","family":"DE WEERD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CJ","family":"STAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRARD A","family":"KERKHOF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHAN B","family":"ROSMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080413"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mds.870100517","article-title":"Toward a better definition of the restless legs syndrome","volume":"10","author":"The International Restless Legs Syndrome Study Group.","year":"1995","journal-title":"Mov. 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