{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:37:50Z","timestamp":1723160270906},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T00:00:00Z","timestamp":1103673600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>SUMMARY:\u2003<\/jats:bold> Glucocorticoid treatment for steroid\u2010dependent nephrotic syndrome (NS) is associated with severe adverse effects, such as bone fractures and epidural lipomatosis. Furthermore, a high trough level of cyclosporine (CsA) over an extended period of time is known to induce CsA nephropathy. We present a girl with steroid\u2010dependent NS and steroid\u2010induced vertebral compression fractures and epidural lipomatosis who was treated with a high\u2010dose of prednisolone after experiencing several relapses. A high CsA trough level (between 147 and 225\u2003ng\/mL) over a period of only 5\u2003months was effective in improving the vertebral compression fractures, alleviating the epidural lipomatosis by enabling the discontinuation of prednisolone treatment. Thus, high trough levels of CsA over a short period of time may enable prednisolone to be discontinued in cases of steroid\u2010dependent NS without causing any clinical, histological, serum and\/or urinary CsA\u2010related adverse effects.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2004.00341.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T10:57:54Z","timestamp":1103713074000},"page":"414-417","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of high trough levels of cyclosporine for 5\u2003months in a case of steroid\u2010dependent nephrotic syndrome with severe steroid toxicity"],"prefix":"10.1111","volume":"9","author":[{"given":"KENICHI","family":"KANO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUMI","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAEKO","family":"SHIRAIWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AKI","family":"SHIMIZU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIYOSHI","family":"NISHIKURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OSAMU","family":"ARISAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGEKI","family":"TOMITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIHIKO","family":"UEDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,22]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"141","article-title":"Comparison between pre\u2010 and post\u2010treatment renal biopsies in children receiving cyclosporine for idiopathic nephrosis","volume":"42","author":"Habib R","year":"1994","journal-title":"Clin. Nephrol."},{"key":"e_1_2_4_3_2","first-page":"19","article-title":"Comparison between pre\u2010 and post treatment clinical and renal biopsies in children receiving low dose ciclosporine\u2010A for 2 years for steroid\u2010dependent nephrotic syndrome","volume":"52","author":"Kano K","year":"1999","journal-title":"Clin. Nephrol."},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00596585"},{"key":"e_1_2_4_5_2","first-page":"185","article-title":"Steroid\u2010induced epidural lipomatosis in nephrotic children: early recognition with MR imaging","volume":"23","author":"Kano K","year":"1996","journal-title":"Dokkyo J. Med. Sci."},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045553"},{"key":"e_1_2_4_7_2","first-page":"23","article-title":"Cyclosporin A nephropathy: standardization of the evaluation of kidney biopsies","volume":"41","author":"Mihatsch MJ","year":"1994","journal-title":"Clin. 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