{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T20:35:39Z","timestamp":1794429339135,"version":"4.9.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,13]],"date-time":"2005-10-13T00:00:00Z","timestamp":1129161600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p><jats:bold>Background:\u2003<\/jats:bold>  <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia minor is a common heterozygous haemoglobinopathy that is characterized by both microcytosis and hypochromia. It requires no treatment. It has been postulated that low\u2010grade haemolysis, tubular iron deposition and toxins derived from erythrocytes might cause renal tubular damage in adult patients with <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia minor. Our aim was to investigate the renal tubular functions in children with \u03b2\u2010thalassemia minor and to determine its possible harmful effects.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> The study was conducted on 32 children (14 female and 18 male) at the age of 5.8\u2003\u00b1\u20033.1\u2003years (range 2\u201314\u2003years) with <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia minor. The patients were classified as anaemic (haemoglobin (Hb)\u2003\u2264\u200311\u2003g\/dL) (Group 1, <jats:italic>n<\/jats:italic>\u2003=\u200314) and non\u2010anaemic (Hb\u2003&gt;\u200311\u2003g\/dL) (Group 2, <jats:italic>n<\/jats:italic>\u2003=\u200318). A control group was formed with 18 healthy children whose ages and sexes match those in other groups (Group 3, <jats:italic>n<\/jats:italic>\u2003=\u200318). Fractional excretion of sodium (FE<jats:sub>Na<\/jats:sub>, %), fractional excretion of magnesium (FE<jats:sub>Mg<\/jats:sub>, %), fractional excretion of uric acid (FE<jats:sub>UA<\/jats:sub>, %) and tubular phosphorus reabsorption (TPR,%) were calculated with standard formulas. Urinary calcium excretion (mg\/kg per 24\u2003h), zinc (Zn) (\u00b5g\/dL), glucosuria (mg\/dL), <jats:italic>\u03b2<\/jats:italic>\u20102 microglobulin (mg\/dL) and <jats:italic>N<\/jats:italic>\u2010acetyl\u2010<jats:italic>\u03b2<\/jats:italic>\u2013D\u2010glycosaminidase (NAG, U\/mmol creatinine) levels were measured through biochemical methods.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> There was no statistically significant difference among the three groups in terms of the results of FE<jats:sub>Na<\/jats:sub> (%), FE<jats:sub>Mg<\/jats:sub> (%), FE<jats:sub>UA<\/jats:sub> (%), TPR (%), calciuria (mg\/kg per 24\u2003h), NAG, urine Zn, proteinuria, glucosuria or urine <jats:italic>\u03b2<\/jats:italic>\u2010 2 microglobulin levels (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> On the contrary of children with <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia major, renal tubular dysfunction has not been determined in children with <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia minor in the present study.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2005.00484.x","type":"journal-article","created":{"date-parts":[[2005,10,13]],"date-time":"2005-10-13T07:50:52Z","timestamp":1129189852000},"page":"427-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Renal tubular function in children with \u03b2\u2010thalassemia minor"],"prefix":"10.1111","volume":"10","author":[{"given":"S\u00dcLEYMAN","family":"KALMAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A AVNI","family":"ATAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ONUR","family":"SAKALLIO\u1e20LU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TANER","family":"\u00d6ZG\u00dcRTA\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FAYSAL","family":"G\u00d6K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISMAIL","family":"KURT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A EMIN","family":"K\u00dcREK\u00c7I","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OKAN","family":"\u00d6ZCAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERDAL","family":"G\u00d6K\u00c7AY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,13]]},"reference":[{"issue":"8","key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/clinchem\/46.8.1284","article-title":"Laboratory investigation of hemoglobinopathies and thalassemias: Review and update","volume":"46","author":"Clarke GM","year":"2000","journal-title":"Clin. Chem."},{"key":"e_1_2_5_3_2","first-page":"21","article-title":"Analysis of thalassemia syndromes and abnormal hemoglobins in patients from the Aegean region of Turkey","volume":"44","author":"\u00ddrken G","year":"2002","journal-title":"Turk. J. Pediatr."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000434"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050453"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000064463"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.08.016"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(92)90822-U"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1999)13:3<95::AID-JCLA1>3.0.CO;2-L"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00467-003-1067-7","article-title":"Renal tubular dysfunction in \u03b1\u2010thalassemia","volume":"18","author":"Sumboonnanonda A","year":"2003","journal-title":"Pediat. 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