{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:41:08Z","timestamp":1774640468908,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p><jats:bold>Background:\u2003<\/jats:bold> Poor control of bone mineral metabolism (BMM) is associated with renal osteodystrophy and mortality in dialysis\u2010dependent patients. The authors explored the efficacy of alternate nightly home haemodialysis (ANHHD) in controlling BMM parameters and its effects on bone mineral density and histomorphometry.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> In this prospective observational study, 26 patients on home haemodialysis (3\u20135\u2003h, 3.5\u20134 sessions weekly) were converted to ANHHD (6\u20139\u2003h, 3.5\u20134 sessions weekly). Biochemical parameters of BMM at baseline, 6 and 12\u2003months, radiological parameters at baseline and 12\u2003months and bone histomorphometry at 12\u2003months are described.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Pre\u2010dialysis serum phosphate fell from 2.13\u2003\u00b1\u20030.65 to 1.38\u2003\u00b1\u20030.35\u2003mmol\/L; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001. No binders were required in 77.2% compared with 7.7% at baseline. Calcium\u2010phosphate product fell from 5.28\u2003\u00b1\u20031.64 to 3.42\u2003\u00b1\u20030.88\u2003mmol<jats:sup>2<\/jats:sup>\/L<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001 and parathyroid hormone (PTH) from 301 (110\u2013471) to 127 (47\u2013240)\u2003ng\/L; <jats:italic>P<\/jats:italic>\u2003=\u20030.01. Bone mineral density remained stable. Vascular and ectopic calcification improved or stabilized in 87.5%. Bone histomorphometry at 12\u2003months showed high, normal and low bone turnover in 10, 3 and 4 patients, respectively, with 6\/17 patients having abnormal mineralization.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Alternate nightly home haemodialysis effectively manages biochemical parameters of BMM. Patients with very high PTH at baseline (&gt;1000\u2003ng\/L) did not significantly improve parathyroid hormone status. Abnormal bone turnover and mineralization were present in a significant proportion of patients at 12\u2003months but low turnover was uncommon. Vascular calcification was stabilized or improved in the majority. ANHHD compares favourably with every night and short daily therapy in relation to BMM management and may offer lifestyle advantages for patients.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2006.00712.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T01:28:30Z","timestamp":1170811710000},"page":"224-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mineral metabolism, bone histomorphometry and vascular calcification in alternate night nocturnal haemodialysis"],"prefix":"10.1111","volume":"12","author":[{"given":"CAROLYN L","family":"VAN EPS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANINE K","family":"JEFFRIES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN A","family":"ANDERSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICK T","family":"BERGIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID W","family":"JOHNSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SCOTT B","family":"CAMPBELL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SALLY M","family":"CARPENTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NICOLE M","family":"ISBEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID W","family":"MUDGE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL M","family":"HAWLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","unstructured":"SlininY FoleyR CollinsA.Calcium phosphorus parathyroid hormone and cardiovascular disease in haemodialysis patients: The USRDS waves 1 3 and 4 study.J. 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