{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:03Z","timestamp":1787773023701,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T00:00:00Z","timestamp":1170892800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold>To analyse the clinical and pathological characteristics of Chinese patients with immune complex deposition in kidney in anti\u2010neutrophil cytoplasmic antibodies (ANCA)\u2010positive vasculitis.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold>Enrolled in this study are patients with immune complex deposition in kidney in ANCA\u2010positive vasculitis diagnosed in Peking University First Hospital. Their clinical and pathological data were collected and analysed.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold>Twenty\u2010three patients were eligible. Fifteen patients were with microscopic polyangiitis and eight patients were with Wegener's granulomatosis. The mean age was 48.8\u2003years and with a male\/female ratio of 10\/13. The interval, between onset of disease and the diagnosis of disease, was 429.6\u2003\u00b1\u2003693.3\u2003days. All patients had clinical evidence of renal involvement. The major immunoglobulin deposited was IgM and the main locations were mesangial and sub\u2010epithelial area. Four patients also presented features of membranous nephropathy and six patients presented features of IgA nephropathy. About 52.2% of patients had hypocomplementaemia. All patients received immunosuppressive therapy and all of them achieved clinical remission. Patients were followed for about 28.8\u2003\u00b1\u200325.3\u2003months. Nine patients kept clinical remission, nine patients progressed to end\u2010stage renal disease and five patients died. When these patients are compared with patients who had classical pauci\u2010immune vasculitis, they had greater proteinuria (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), higher prevalence of hypocomplementaemia (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and greater glomerular cellularity (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold>The present study showed that the features of patients with ANCA\u2010associated vasculitis with immune complex deposition in kidney were similar with classical \u2018pauci\u2010immune\u2019 vasculitis except for more proteinuria, more hypocomplementaemia and greater glomerular hypercellularity.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2006.00713.x","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T16:48:43Z","timestamp":1170953323000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical and pathological characteristics and outcomes of Chinese patients with primary anti\u2010neutrophil cytoplasmic antibodies\u2010associated systemic vasculitis with immune complex deposition in kidney"],"prefix":"10.1111","volume":"12","author":[{"given":"FENG","family":"YU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MIN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SU\u2010XIA","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WAN\u2010ZHONG","family":"ZOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MING\u2010HUI","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAI\u2010YAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"JennetteJC FalkR AndrassyKet\u2003al.Nomenclature of systemic vasculitis: Proposal of an international consensus conference.Arthritis Rheum.1994;37:187\u201392."},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","unstructured":"HaasM JafriJ BartoshSM KarpSL AdlerSG MeehanSM.ANCA\u2010associated crescentic glomerulonephritis with mesangial IgA deposits.Am. 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