{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:49:40Z","timestamp":1776995380416,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,12]],"date-time":"2007-07-12T00:00:00Z","timestamp":1184198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p><jats:bold>Background:\u2003<\/jats:bold> Haemodialysis (HD) patients with diabetes mellitus often have renal osteodystrophy (ROD) characterized by reduced bone turnover, but little is known about the correlation between bone formation and bone resorption in this population.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> The authors measured serum parathyroid hormone (PTH), bone alkaline phosphatase (BAP), N\u2010telopeptides of type 1 collagen (NTx) and fasting glucose in 48 patients with diabetic nephropathy (DN) and 80 patients with glomerulonephritis (non\u2010DN) who had received \u226410\u2003years of regular HD. Spearman's correlation coefficients (<jats:italic>r<\/jats:italic>) were derived.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> In the whole patients, the DN group had a lower PTH and NTx level than the non\u2010DN group. Serum PTH was not correlated with NTx in the DN group, whereas all three markers were correlated with each other in the non\u2010DN group. Subdividing the DN patients according to HD duration revealed remarkable differences in the correlation between BAP and NTx: in patients receiving \u22655\u2003years HD (<jats:italic>r<\/jats:italic>\u2003=\u20030.568) this correlation was similar to that in the non\u2010DN group (<jats:italic>r<\/jats:italic>\u2003=\u20030.653), whereas there was no significant correlation in those receiving &lt;5\u2003years HD. Patients receiving \u22655\u2003years HD had a comparable glucose level (111.1\u2003\u00b1\u200319.2\u2003mg\/dL) to the non\u2010DN group, whereas those receiving &lt;5\u2003years had a higher level (196.1\u2003\u00b1\u200353.1\u2003mg\/dL).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Differences in the interaction between bone cells between DN and non\u2010DN patients are one potential cause of lower bone turnover in the former group. Research of this correlation is needed to increase understanding of the complexities of bone metabolism in DN patients.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2007.00829.x","type":"journal-article","created":{"date-parts":[[2007,7,12]],"date-time":"2007-07-12T23:21:12Z","timestamp":1184282472000},"page":"539-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between parathyroid hormone, bone alkaline phosphatase and N\u2010telopeptide of type 1 collagen in diabetic and non\u2010diabetic haemodialysis patients"],"prefix":"10.1111","volume":"12","author":[{"given":"NOBUNORI","family":"TAKAHASHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIHISA","family":"KOJIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"OGAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAOKI","family":"ISHIGURO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","unstructured":"InabaM OkunoS NagasueKet\u2003al.Impaired secretion of parathyroid hormone is coherent to diabetic hemodialyzed patients.Am. 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