{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:27:42Z","timestamp":1768526862634,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T00:00:00Z","timestamp":1265328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> Renal expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) contribute to the development of tubulointerstitial fibrosis characteristic of progressive forms of primary glomerulonephritis (GN).<\/jats:p><jats:p>The aim of this study was to investigate the therapeutic effect of MMP inhibitor, doxycycline, administration in an experimental rat model of immune\u2010complex nephritis (ICN).<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> The induction of immune\u2010complex glomerulonephritis was carried out by the administration of an i.v. dose of 2\u2003mg bovine serum albumin (BSA) daily for 28\u2003days after 8\u2003weeks of s.c. immunization with 1\u2003mg of BSA in complete Freund's adjuvant. Doxycycline (30\u2003mg\/kg) was given daily (in groups 2 and 4) by gavage for 28\u2003days.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Animals treated with doxycycline showed significant reduction in glomerular area and cell proliferation than non\u2010treated controls. Glomerular deposition of immunoglobulin (Ig)G and C3 was less intense in treated rats than non\u2010treated controls. Although not statistically significant, interstitial inflammation was less intense in treated rats than non\u2010treated controls. Glomerular expression of MMP\u20109 by immunoflourescence was significantly inhibited in the treated group. In addition pro\u2010MMP\u20102 on gelatin zymography was importantly suppressed by doxycycline in ICN.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Doxycycline, in addition to its antibiotic property, may, following further investigation, provide a possible survival benefit in proliferative glomerulonephritis.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2010.01289.x","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T12:57:57Z","timestamp":1265374677000},"page":"560-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune\u2010complex nephritis"],"prefix":"10.1111","volume":"15","author":[{"given":"FUNDA","family":"SAGLAM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALI","family":"CELIK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEVRIM","family":"TAYFUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZAHIDE","family":"CAVDAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OSMAN","family":"YILMAZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SULEN","family":"SARIOGLU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EFSUN","family":"KOLATAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GULGUN","family":"OKTAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TANER","family":"CAMSARI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.95"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.12.2873"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-9005-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl743"},{"key":"e_1_2_5_6_2","first-page":"85","article-title":"Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex\u2010mediated glomerulonephritis","volume":"141","author":"Lovett DH","year":"1992","journal-title":"Am. 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