{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:37:13Z","timestamp":1778855833654,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T00:00:00Z","timestamp":1296086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Aim:\u2003<\/jats:bold>\n                    SM22\u03b1 (transgelin) has been focused upon as a player in the process of phenotypic changes of types of cells. The SM22\u03b1 expression in the rat anti\u2010glomerular basement membrane (GBM) nephritis model and differences from an established phenotypic marker for the myofibroblast, \u03b1\u2010smooth muscle actin (\u03b1SMA), were investigated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2003<\/jats:bold>\n                    The rat kidney tissues were processed for histological studies, immunohistochemical and immunoelectronmicroscopy analyses on days 0, 7, 28, 42 and 56 after injection of rabbit anti\u2010GBM serum for the disease induction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2003<\/jats:bold>\n                    Immunohistochemistry with anti\u2010SM22\u03b1 antibodies (Ab) revealed that kidneys of the nephritic rats on day 7 expressed SM22\u03b1 in podocytes, crescentic cells and epithelial cells of Bowman's capsule. After 28\u2003days, SM22\u03b1 was also expressed in peritubular interstitial cells. Double immunofluorescence with anti\u2010SM22\u03b1 Ab and anti\u2010\u03b1SMA Ab showed that SM22\u03b1 was preferentially expressed in podocytes, whereas \u03b1SMA was positive in mesangial cells on day 7. After day 28, both molecules became positive in peritubular interstitial cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2003<\/jats:bold>\n                    SM22\u03b1 was expressed in epithelial cells of inflamed glomeruli in the early phase, and then also in peritubular interstitial cells in the later phase of anti\u2010GBM nephritis model. SM22\u03b1 presented unique kinetics of expression distinct from \u03b1SMA.\n                  <\/jats:p>","DOI":"10.1111\/j.1440-1797.2010.01322.x","type":"journal-article","created":{"date-parts":[[2010,3,20]],"date-time":"2010-03-20T20:13:46Z","timestamp":1269116026000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Injured kidney cells express SM22\u03b1 (transgelin): Unique features distinct from \u03b1\u2010smooth muscle actin (\u03b1SMA)"],"prefix":"10.1111","volume":"16","author":[{"given":"YUICHI","family":"SAKAMAKI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MINORU","family":"SAKATSUME","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XINGZHI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGERU","family":"INOMATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TADASHI","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FUMITAKE","family":"GEJYO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ICHIEI","family":"NARITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2440705"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.121.5.1065"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(89)90108-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1993.tb00027.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.1016\/S0021-9258(18)45526-3","article-title":"Amino acid sequence of chicken gizzard smooth muscle SM22 alpha","volume":"262","author":"Pearlstone JR","year":"1987","journal-title":"J. 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