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FGF\u201023 levels are inversely related to renal function and in patients with chronic kidney disease (CKD) elevation in FGF\u201023 precedes the rise of serum phosphate. Studies have demonstrated an important role for FGF\u201023 in the development of secondary hyperparathyroidism through an effect on parathyroid hormone and calcitriol. In cross\u2010sectional studies FGF\u201023 has been associated with surrogate markers of cardiovascular disease such as endothelial dysfunction and arterial stiffness. FGF\u201023 has also been associated with both progression of CKD and mortality in dialysis patients. 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