{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:49:35Z","timestamp":1767970175433,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF\u2010\u03b21 levels in children with obstructive and non\u2010obstructive uropathies (NOU).<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> This study involved 19 children with OU, 11 children with non\u2010obstructive hydronephrosis and 21 healthy children. Urinary TGF\u2010\u03b21, proteinuria, microalbuminuria and urinary \u03b11\u2010microglobulin were measured, and renal function was assesed. The results were statistically analyzed.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Mean urinary TGF\u2010\u03b21 concentrations in patients with OU were significantly higher than those with NOU (4.14\u2003\u00b1\u20030.67 creatinine <jats:italic>vs<\/jats:italic> 1.80\u2003\u00b1\u20030.24\u2003pg\/mmol creatinine, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and healthy controls (1.66\u2003\u00b1\u20030.28\u2003pg\/mmol creatinine, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Positive correlations of urinary TGF\u2010\u03b21 concentrations with proteinuria (<jats:italic>r<\/jats:italic>\u2003=\u20030.87, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and urinary \u03b11\u2010microglobulin (<jats:italic>r<\/jats:italic>\u2003=\u20030.82, <jats:italic>P<\/jats:italic>\u2003=\u20030.0002) were found in patients with OU.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Children with OU have higher urinary TGF\u2010\u03b21 than children with NOU. Urinary TGF\u2010\u03b21 may be a useful non\u2010invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF\u2010\u03b21 with markers of renal tissue damage in patients with OU was found.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2011.01459.x","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T07:07:24Z","timestamp":1299568044000},"page":"595-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Urinary transforming growth factor\u2010\u03b21 in children with obstructive uropathy"],"prefix":"10.1111","volume":"16","author":[{"given":"JAKUB","family":"ZIEG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KVETA","family":"BLAHOVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMAS","family":"SEEMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIRI","family":"BRONSKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANA","family":"DVORAKOVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTA","family":"PECHOVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"JANDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAREL","family":"MATOUSOVIC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050756"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/snep.2001.20942"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000193287.56528.a4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64416-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68056-X"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00331-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06641.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002400050146"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01156-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02012459"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00866741"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365510510013596"},{"key":"e_1_2_6_14_2","first-page":"233","article-title":"Is serum cystatin\u2010C a suitable marker of renal function in children?","volume":"37","author":"Zafanello M","year":"2007","journal-title":"Ann. 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