{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:16:51Z","timestamp":1758280611623},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T00:00:00Z","timestamp":1319673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> Carotid artery intima media thickness (CA\u2010IMT) measurement has been shown to be a safe and reproducible method to assess severity of atherosclerosis. The association between nephrosclerosis and systemic atherosclerosis is not clear. In this study, we investigated the association between CA\u2010IMT and nephrosclerosis in a group of kidney transplant donors.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Forty seven potential kidney transplant donors were included. CA\u2010IMT was measured by B\u2010Mode ultrasonography. Kidney allograft biopsy samples were obtained during the transplantation operation and chronic glomerular, vascular and tubulointertitial changes were semiquantitatively scored according to the Banff classification.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Mean age was 52\u2003\u00b1\u200312\u2003years and 55% of the cases were younger than 55\u2003years. Mean CA\u2010IMT was 0.74\u2003\u00b1\u20030.19\u2003mm and 48% had IMT values &gt;\u20030.75\u2003mm. Chronicty index was \u22655 in 55% of the cases. Chronicity index was higher in cases older than 55\u2003years. Age and CA\u2010IMT were significantly correlated with chronic vascular changes and chronicity index. CA\u2010IMT\u2003&gt;\u20030.75\u2003mm had a 46% sensitivity and 90% specificity to predict nephrosclerosis. Positive and negative predictive values were 85% and 57%, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Aging leads to detrimental changes in every part of the vasculature of the human body. CA\u2010IMT is correlated with the level of nephrosclerosis. Measurement of CA\u2010IMT reflects nephrosclerosis especially in older patients.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2011.01499.x","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T01:55:11Z","timestamp":1311213311000},"page":"720-724","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nephrosclerosis and carotid atherosclerosis: Lessons from kidney donor histology"],"prefix":"10.1111","volume":"16","author":[{"given":"SINAN","family":"ERTEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OZKAN","family":"GUNGOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAIT","family":"SEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUREYYA S.","family":"OZBEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FATIH","family":"KIRCELLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CUNEYT","family":"HOSCOSKUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUSEYIN","family":"TOZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GULAY","family":"ASCI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALI","family":"BASCI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERCAN","family":"OK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-9-201005040-00006"},{"key":"e_1_2_5_3_2","first-page":"286","article-title":"Histopathological findings in elderly patients","volume":"32","author":"Carmo PA","year":"2010","journal-title":"J. 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