{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:34:13Z","timestamp":1790177653308,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> Uraemia is associated with hyperprolactinaemia, low total (TT) and free (FT) serum testosterone, high luteinizing hormone (LH) and follicle\u2010stimulating hormone (FSH) and, in women, anovulatory cycles and premature menopause. We hypothesize that extended hours haemodialysis may improve these derangements.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> This is an observational cohort study of 30 men (age 54\u2003\u00b1\u200313\u2003years, body mass index (BMI) 28.1\u2003\u00b1\u20035.8\u2003kg\/m<jats:sup>2<\/jats:sup>) and seven women (age 41\u2003\u00b1\u200311\u2003years, BMI 32.2\u2003\u00b1\u200311.2\u2003kg\/m<jats:sup>2<\/jats:sup>) established on chronic home haemodialysis (3\u20135\u2003h, 3.5\u20135 sessions weekly) who were converted to nocturnal home haemodialysis (6\u20139\u2003h, 3.5\u20135 sessions weekly). Serum was collected at baseline and 6\u2003months for measurement of TT, sex hormone binding globulin (SHBG), LH, FSH, prolactin, thyroid\u2010stimulating hormone and thyroxine.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> In the male patients (<jats:italic>n<\/jats:italic>\u2003=\u200325), serum prolactin significantly fell (281 (209.5\u2013520) <jats:italic>vs<\/jats:italic> 243 (187\u2013359)\u2003mU\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.001) and TT (12.6\u2003\u00b1\u20035.8 <jats:italic>vs<\/jats:italic> 15.2\u2003\u00b1\u20038.1\u2003nmol\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.06) and FT (281\u2003\u00b1\u2003118 <jats:italic>vs<\/jats:italic> 359\u2003\u00b1\u2003221\u2003pmol\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.01) increased. SHBG, LH and FSH were unchanged. At 6\u2003months, two of the three women under 40\u2003years of age had return of regular menses after being amenorrhoeic or having prolonged and irregular menses at baseline. There were insufficient women in this study to further analyse changes in sex hormone levels. Thyroid function tests remained stable.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Alternate nightly nocturnal haemodialysis significantly improves hyperprolactinaemia and hypotestosteronaemia in men. Menstrual cycling may be re\u2010established in young women. The effect of these changes on fertility has not been established. Patients should be counselled about the possibility of increased fertility before conversion to extended hours haemodialysis regimens.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2011.01520.x","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T13:33:31Z","timestamp":1315920811000},"page":"42-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Changes in serum prolactin, sex hormones and thyroid function with alternate nightly nocturnal home haemodialysis"],"prefix":"10.1111","volume":"17","author":[{"given":"CAROLYN","family":"VAN EPS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARMEL","family":"HAWLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANINE","family":"JEFFRIES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID W","family":"JOHNSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SCOTT","family":"CAMPBELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICOLE","family":"ISBEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID W","family":"MUDGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHANNES","family":"PRINS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1061381"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0837"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2004.07.008"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008060664"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000186119"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.4065\/73.11.1035"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451725"},{"key":"e_1_2_6_9_2","unstructured":"The KDQOL form and instructions for use can be found at the following website:http:\/\/www.gim.med.ucla.edu\/kdqol\/[Cited January 2004]."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199501000-00009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(99)90236-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-007-9277-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.12.045"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh192"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)03994-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000064079"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.14624.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00712.x"},{"issue":"12","key":"e_1_2_6_19_2","first-page":"CD007747","article-title":"Interventions for treating sexual dysfunction in patients with chronic kidney disease","volume":"8","author":"Vecchio M","year":"2010","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1797.2011.01520.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1797.2011.01520.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:57:14Z","timestamp":1697284634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1797.2011.01520.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1440-1797.2011.01520.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1797.2011.01520.x","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,28]]},"assertion":[{"value":"2011-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}