{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:25:18Z","timestamp":1788643518904,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> To evaluate the compassionate use of cinacalcet for the management of secondary hyperparathyroidism in patients who are not on dialysis.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Patients with stage 4\u20135 chronic kidney disease (CKD) who were not on dialysis, had an intact parathyroid hormone (iPTH) level greater than 300\u2003pg\/mL, and had not responded satisfactorily to treatment with phosphate binders and vitamin D were prospectively studied. Patients received 6\u2003months of compassionate treatment with cinacalcet, which was initiated at a dose of 30\u2003mg\/day orally and flexibly dosed thereafter based on iPTH levels.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Twenty\u2010six patients with a mean age\u2003\u00b1\u2003standard deviation (SD) of 58.8\u2003\u00b1\u200316.1\u2003years were enrolled in the study and included in the statistical analysis. The mean percentage change in iPTH levels from baseline after 6\u2003months of treatment was \u221267.9\u2003\u00b1\u200317.0%, with 92.3% (95% confidence interval (CI), 75.9\u201397.9) of patients showing an iPTH level within the limits recommended by Kidney Disease Outcomes Quality Initiative (K\/DOQI) guidelines. The mean serum calcium concentrations had decreased significantly at the end of the study (\u22128.0\u2003\u00b1\u20036.9%), while the mean serum phosphorus concentration had significantly increased (+8.3\u2003\u00b1\u200317.0%).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Our results suggest that cinacalcet may be a useful alternative for the treatment of secondary hyperparathyroidism in pre\u2010dialysis patients who are unresponsive to other treatments. The hypocalcemia and hyperphosphatemia reported in previous studies may not occur if a moderate dose of calcimimetics is used in patients with marginal glomerular filtration rates, especially if combined with vitamin D analogues and calcium\u2010based phosphate binders.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2011.01530.x","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T05:58:45Z","timestamp":1319522325000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of cinacalcet for the treatment of secondary hyperparathyroidism in patients with advanced chronic kidney disease before initiation of regular dialysis"],"prefix":"10.1111","volume":"17","author":[{"given":"JES\u00daS","family":"MONTENEGRO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00d1AKI","family":"CORNAGO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABEL","family":"GALLARDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAULA","family":"GARC\u00cdA\u2010LEDESMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AINHOA","family":"HERNANDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABEL","family":"MARTINEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSA I","family":"MU\u00d1OZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCO A","family":"ROMERO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90330-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2007.13.5.397"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2009.00581.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.1.18"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425250802587017"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00302.2004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.04.013"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.09.021"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0821"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.54"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.002"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0191"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0832"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"issue":"4","key":"e_1_2_6_16_2","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","author":"National Kidney Foundation","year":"2003","journal-title":"Am. 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