{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:39:14Z","timestamp":1760708354625},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T00:00:00Z","timestamp":1329955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> Minimal\u2010change nephrotic syndrome (MCNS) is characterized by a good response to corticosteroid, but a high incidence of relapse. We compared the effect of intravenous methylprednisolone pulse plus oral prednisolone therapy (pulse group) with that of conventional oral prednisolone alone therapy (oral group) on the responsiveness and relapse in the first attack of adult\u2010onset MCNS patients.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Eighty\u2010one adult patients with biopsy\u2010proven MCNS, who were previously untreated and admitted to our hospital with their first attack of nephrotic syndrome, were analyzed retrospectively. They were arbitrarily assigned to either pulse group (<jats:italic>n<\/jats:italic>\u2003=\u200329, 1000\u2003mg of methylprednisolone intravenously for 3\u2003days, and then oral prednisolone 30 to 40\u2003mg daily for 4 to 8\u2003weeks) or oral group (<jats:italic>n<\/jats:italic>\u2003=\u200352, oral prednisolone 1\u2003mg\/kg daily for 4 to 8\u2003weeks). We compared the time to response and relapse between the two groups.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Time to steroid response was significantly shorter in the pulse group compared with the oral group (15.2\u2003\u00b1\u200310.2 <jats:italic>vs<\/jats:italic> 26.7\u2003\u00b1\u200317.6\u2003days, <jats:italic>P<\/jats:italic>\u2003=\u20030.03). In 74 patients who reached remission within 12\u2003weeks (pulse <jats:italic>vs<\/jats:italic> oral groups; 86.2% <jats:italic>vs<\/jats:italic> 96.2%, ns), the time to relapse was not different between two groups but the relapse rate was significantly higher in the pulse group (pulse <jats:italic>vs<\/jats:italic> oral groups; 60% <jats:italic>vs<\/jats:italic> 35%, <jats:italic>P<\/jats:italic>\u2003=\u20030.038). Kaplan\u2013Meier analyses revealed that both complete remission rates within 4\u2003weeks of the initial steroid therapy and relapse rate within 12\u2003months after attaining remission were significantly higher in the pulse group than the oral group. In the Cox regression model, intravenous methylprednisolone pulse therapy had a significant effect on relapse (hazard ratio, 2.39 (95% confidence interval 1.11\u20135.15), <jats:italic>P<\/jats:italic>\u2003=\u20030.026).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Intravenous methylprednisolone pulse followed by oral prednisolone therapy shows an earlier responsiveness but a much more frequent relapse compared with conventional oral prednisolone alone therapy for the first attack of adult\u2010onset MCNS.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2011.01544.x","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T17:59:40Z","timestamp":1322157580000},"page":"263-268","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of the effects of intravenous methylprednisolone pulse <i>versus<\/i> oral prednisolone therapies on the first attack of minimal\u2010change nephrotic syndrome in adults"],"prefix":"10.1111","volume":"17","author":[{"given":"KEIICHI","family":"FUKUDOME","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHOUICHI","family":"FUJIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUJI","family":"SATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUO","family":"KITAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80353-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.31400"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-007-0484-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03531006"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5720.421"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6215.685"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6505.1305"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1983.tb04479.x"},{"issue":"1","key":"e_1_2_5_10_2","first-page":"1","article-title":"Interventions for minimal change disease in adults with nephrotic syndrome","author":"Palmer SC","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.130"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000167603"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027136"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046215"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1797.2011.01544.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1797.2011.01544.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:58:38Z","timestamp":1697309918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1797.2011.01544.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,23]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1440-1797.2011.01544.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1797.2011.01544.x","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,23]]},"assertion":[{"value":"2012-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}