{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:16:22Z","timestamp":1778728582340,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T00:00:00Z","timestamp":1329955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> Interleukin\u20106 (IL\u20106) is secreted from adipose tissue and thought to contribute to obesity\u2010related disorders. The aim of this study was to assess if IL\u20106\u2010knockout (IL\u20106\u2010\/\u2010) mice would develop obesity\u2010induced renal impairment.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Wild\u2010type (WT) and IL\u20106\u2010\/\u2010 mice were high\u2010fat fed (HFF) for 16\u2003weeks to induce obesity. At the end of the study, renal function was measured via albumin\/creatinine ratio and serum creatinine levels, using enzyme\u2010linked immunosorbent assay (ELISA) and high\u2010performance liquid chromatography (HPLC). Glomerulosclerotic index (GSI) was scored in periodic acid Schiff\u2010stained sections and collagen IV accumulation was assessed by immunohistochemistry. Renal cortical tumour growth factor beta (TGF\u2010\u03b2<jats:sub>1<\/jats:sub>) activity and monocyte chemotactic protein\u20101 (MCP\u20101) levels were measured via ELISA.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Renal IL\u20106 concentrations were increased with obesity. Although both WT HFF and IL\u20106\u2010\/\u2010 HFF mice exhibited renal impairment as measured by increased serum creatinine and urinary albumin\/creatinine ratios, this was exacerbated in IL\u20106\u2010\/\u2010 mice. Obese mice had renal activation of cortical TGF\u2010\u03b2<jats:sub>1<\/jats:sub>, which was also higher in IL\u20106\u2010\/\u2010 mice. Collagen IV staining was not affected by obesity. GSI was increased with obesity in both WT and IL\u20106\u2010\/\u2010 mice.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Obese IL\u20106\u2010\/\u2010 mice demonstrated renal functional and structural abnormalities above that seen in obese WT mice. We suggest that absence or low IL\u20106 levels may be an important accelerating factor implicated in the development and progression of obesity\u2010induced renal disease.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2011.01547.x","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T22:34:48Z","timestamp":1322778888000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Obesity\u2010induced renal impairment is exacerbated in interleukin\u20106\u2010knockout mice"],"prefix":"10.1111","volume":"17","author":[{"given":"BROOKE E","family":"HARCOURT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSEPHINE M","family":"FORBES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VANCE B","family":"MATTHEWS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.173534"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060501"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.01.034"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050822"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.02.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.5.E745"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00074.2009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1681\/ASN.V82208","article-title":"Circulating serum lectins of patients with IgA nephropathy stimulate IL\u20106 release from mesangial cells","volume":"8","author":"Libetta C","year":"1997","journal-title":"J. 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