{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:26:29Z","timestamp":1767824789690,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,24]],"date-time":"2012-06-24T00:00:00Z","timestamp":1340496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> We designed a cross\u2010sectional study to investigate plasma vitamin C level in patients who underwent maintenance haemodialysis (MHD) and continuous ambulatory peritoneal dialysis (CAPD) to explore whether there is a difference in vitamin C deficiency between MHD patients and CAPD patients.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> This investigation included 382 dialysis patients without vitamin C supplement before the study. Demographic characteristics, laboratory tests, ascorbic acid and total plasma vitamin C level were measured. A linear regression model was built to explore the association between vitamin C deficiency and dialysis modalities after adjusting for age, dialysis vintage, gender, Charlson index, modality of dialysis and hsCRP.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> The range of plasma vitamin C level was from 0.48\u2003\u00b5g\/mL to 31.16\u2003\u00b5g\/mL. 35.9% (<jats:italic>n<\/jats:italic>\u2003=\u2003137) patients had severe vitamin C deficiency (&lt;2\u2003\u00b5g\/mL). Plasma vitamin C level was inversely associated with age and dialysis vintage. After age and dialysis vintage were adjusted, vitamin C deficiency was associated with MHD. R square for model fitting was relatively low, which implied that there were other vitamin C influencing factors not included in the model.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Vitamin C deficiency is common in dialysis patients, especially in patients treated with MHD.<\/jats:p>","DOI":"10.1111\/j.1440-1797.2012.01595.x","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T06:05:41Z","timestamp":1331273141000},"page":"452-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association between vitamin C deficiency and dialysis modalities"],"prefix":"10.1111","volume":"17","author":[{"given":"KUNYING","family":"ZHANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIE","family":"DONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XUYANG","family":"CHENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENYING","family":"BAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WEIYA","family":"GUO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEIYUN","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LI","family":"ZUO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.422"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1681\/ASN.V7112320","article-title":"Secondary oxalosis: A cause of delayed recovery of renal function in the setting of acute renal failure","volume":"7","author":"Alkhunaizi AM","year":"1996","journal-title":"J. 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