{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:41:49Z","timestamp":1698133309058},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T00:00:00Z","timestamp":1205712000000},"content-version":"vor","delay-in-days":5676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> The plasma ratio of each neutral amino acid (tryptophan (TRP), tyrosine (TYR), valine, isoleucine, leucine (LEU) or phenylalanine) to the sum of the other neutral amino acids was measured in <jats:bold>16<\/jats:bold>: manic and <jats:bold>14<\/jats:bold>: depressed patients. In the manics, there was a correlation between the psychomotor activity and the plasma TRP and LEU ratios. In the depressives, the depressed mood, retardation and global severity were correlated with the TRP ratio. The zotepine responders showed an increase in the TRP ratio after treatment. In the mianserin responders, the TYR ratio, which was high before the treatment, decreased to the normal range after the treatment. But, the plasma amino acid ratios remained unchanged in the patients treated with lithium carbonate or amitriptyhe. These results suggest that, in manic\u2010depressive illness, there might be abnormalities in the metabolism of neutral amino acids, mainly of TRP and TYR, and that the plasma TRP and TYR ratios might be important indicators for determining the efflcacy of some drugs.<\/jats:p>","DOI":"10.1111\/j.1440-1819.1992.tb00546.x","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T14:42:04Z","timestamp":1205764924000},"page":"711-720","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Ratios of Tryptophan and Tyrosine to Other Large Neutral Amino Acids in Manic\u2010Depressive Patients"],"prefix":"10.1111","volume":"46","author":[{"given":"Motohisa","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KO","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Kumashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"319","article-title":"Reduced plasma cyclic AMP level during prophylactic lithium treatment in patients with affective disorders","volume":"15","author":"Arato M.","year":"1980","journal-title":"Biol Psychiatry"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00505077"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.135.5.385"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(72)90018-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408447709003378"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780310042003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790080115018"},{"key":"e_1_2_1_9_2","first-page":"55","article-title":"Diet\u2010induced changes in plasma amino acid pattern: Effects on the brain uptake of large neutral amino acids, and on brain serotonin synthesis","volume":"15","author":"Fernstrom J.D.","year":"1979","journal-title":"J Neural Transm Suppl"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1983.63.2.484"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3992.149"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4059.414"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0374-84"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.1974.tb02290.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb04308.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1016\/S0021-9258(19)70391-3","article-title":"The effects of lithium ion and other agents on the activity of myoinositol\u20101\u2010phosphatase from bovine brain","volume":"225","author":"Hallcher L.M.","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_1_18_2","first-page":"473","article-title":"Possible relationship between antimanic effect and activity of zotepine to 5\u2010HTl receptor","volume":"38","author":"Harada T.","year":"1984","journal-title":"Folia Psychiatr Neurol Jpn"},{"key":"e_1_2_1_19_2","first-page":"406","article-title":"Antimanic effect of zotepine","volume":"8","author":"Harada T.","year":"1986","journal-title":"Clin Ther"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(86)90329-X"},{"key":"e_1_2_1_21_2","first-page":"505","volume-title":"Psychopharmacology: The Third Generation of Progress","author":"Jimerson D. 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