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The expression of c\u2010Fos\u2010immunoreactivity induced by methamphetamine (6\u2003mg\/kg, intraperitoneally) around the injection site was suppressed until 5 days after injection. Using this method, it was observed that unilateral injection with c\u2010fos antisense ODN into the rat striatum caused robust ipsilateral rotations after methamphetamine challenge 4 days post injection. This method is simple, and the biological and behavioral effects of antisense ODN in WAP can be maintained for several days even after a single injection into the brain.<\/jats:p>","DOI":"10.1111\/j.1440-1819.2004.01296.x","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T14:07:58Z","timestamp":1097503678000},"page":"531-535","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term suppression of methamphetamine\u2010induced c\u2010Fos expression in rat striatum by the injection of c\u2010fos antisense oligodeoxynucleotides absorbed in water\u2010absorbent polymer"],"prefix":"10.1111","volume":"58","author":[{"given":"JUN\u2019ICHI","family":"SEMBA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAKI","family":"WAKUTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TETSUYA","family":"SUHARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00394-X"},{"key":"e_1_2_6_3_2","first-page":"51","article-title":"Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine","volume":"46","author":"Silvia CP","year":"1994","journal-title":"Mol. 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