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Herein, we review adult case report data published during the past quarter\u2010century on adverse corticosteroid\u2010induced psychiatric effects, and present a case of corticosteroid\u2010induced psychotic depression. PubMed and PsychLit databases were searched using the terms \u2018corticosteroids\u2019, \u2018steroids\u2019, and the generic names of corticosteroid medications with terms for psychiatric symptoms or syndromes, including psychosis, mania, hypomania, depression, apathy, anxiety, panic, depersonalization, delirium, confusion, hallucinations, delusions, paranoia, cognitive impairment and dementia. Fifty\u2010five cases and a number of clinical trials investigating the incidence and treatment of these psychiatric symptoms and syndromes were identified. Data on incidence, drug dose, risk factors, course of illness and treatment (when present) were tabulated. We conclude that the cumulative data indicate that psychiatric complications of corticosteroid treatment are not rare and range from clinically significant anxiety and insomnia, to severe mood and psychotic disorders, delirium and dementia. While tapering or discontinuation of the corticosteroid treatment may remedy these adverse side\u2010effects, psychotropic medications are often required because of the medical necessity of the corticosteroid or the severity of the psychiatric symptom. Further studies are needed to better understand the deleterious psychiatric effects associated with corticosteroids.<\/jats:p>","DOI":"10.1111\/j.1440-1819.2011.02260.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:39:25Z","timestamp":1318898365000},"page":"549-560","source":"Crossref","is-referenced-by-count":240,"title":["Psychiatric complications of treatment with corticosteroids: Review with case report"],"prefix":"10.1111","volume":"65","author":[{"given":"Heather A.","family":"Kenna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy W.","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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