{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:53:48Z","timestamp":1761954828682,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":5519,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pathologica Japonica"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>The integrin VLA\u20106 as a laminin receptor and laminin as a ligand for laminin receptor were detected immunohisto\u2010chemically in normal, benign tumor and carcinoma tissues of the breast. Epithelial cells of both normal breast and benign tumor were in almost all cases strongly immuno\u2010reactive for VLA\u20106 in the plasma membrane. Carcinoma cells in 34 of 70 cases (49%) with an invasive component were not immunoreactive for VLA\u20106, and no carcinoma ceils showed strong positivity. Although carcinoma cells in only four of 51 cases (8%) with intraductal components were negative for VLA\u20106, 37 cases (72%) showed weak expression of VLA\u20106 and 10 cases (20%) showed strong expression of VLA\u20106. A concordant expression of VLA\u20106 on carcinoma cells and laminin around carcinoma cell nests with an invasive component was observed, and VLA\u20106 expression in carcinoma cells was correlated to tubular formation in carcinoma cell nests as an indicator of differentiation. These findings suggest that loss of VLA\u20106 plays a role in the invasion of breast carcinoma, and that VLA\u20106 laminin receptor and laminin may contribute to tubular differentiation of breast carcinoma cells.<\/jats:p>","DOI":"10.1111\/j.1440-1827.1993.tb02550.x","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T21:24:19Z","timestamp":1229030659000},"page":"662-669","source":"Crossref","is-referenced-by-count":2,"title":["A role of VLA\u20106 laminin receptor in invasion of breast carcinoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Koji","family":"Arihiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Inai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasima","family":"Khatun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumasa","family":"Kuroi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Toge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"636","article-title":"Tumor invasion and the extracellular matrix","volume":"49","author":"Liotta LA","year":"1983","journal-title":"Lab. Invest."},{"key":"e_1_2_1_3_2","first-page":"339","article-title":"Tumor invasion and metastases, role of the basement membrane","volume":"117","author":"Liotta LA","year":"1984","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"Tumor invasion and metastases, role of the extracellular matrix","volume":"46","author":"Liotta LA","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_2","first-page":"1373","article-title":"Immunodetection of the metastasis\u2010associated laminin receptor in human breast cancer cells obtained by fine\u2010needle aspiration biopsy","volume":"137","author":"Castronovo V","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_6_2","first-page":"1479","article-title":"Independent prognostic value of laminin receptor expression in breast cancer survival","volume":"50","author":"Marques LA","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.1.29"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0232-1513(86)80002-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.03.110187.000421"},{"key":"e_1_2_1_10_2","first-page":"2713","article-title":"Expression of laminin receptor in normal and carcinomatous human tissues as defined by a monoclonal antibody","volume":"45","author":"Hand PH","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61504-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90233-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.10.3239"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68549-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83380-4"},{"key":"e_1_2_1_16_2","first-page":"2395","article-title":"The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin \u03b16\u03b24","volume":"51","author":"Waes CV","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68811-8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.9906"},{"key":"e_1_2_1_19_2","first-page":"487","article-title":"Laminin receptor of platelets is the integrin VLA\u20106","volume":"336","author":"Sonnenberg A","year":"1988","journal-title":"Nafure"},{"key":"e_1_2_1_20_2","first-page":"863","article-title":"Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast","volume":"137","author":"Zutter MM","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711650106"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711650304"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90034-Z"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711670409"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.141"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620202"},{"key":"e_1_2_1_27_2","first-page":"741","article-title":"Expression of VLA\u2010\u03b12, VLA\u2010\u03b16, and VLA\u2010\u03b21 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases","volume":"138","author":"Koretz K","year":"1991","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114379"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/34.8.2426332"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61123-8"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90902-1"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.2.481"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90707-0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.6.2175"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.6.2167"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.2.877"},{"key":"e_1_2_1_38_2","first-page":"5076","article-title":"Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin","volume":"41","author":"Albrechtsen R","year":"1981","journal-title":"Cancer Res."}],"container-title":["Acta Pathologica Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.1993.tb02550.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.1993.tb02550.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T14:49:37Z","timestamp":1705848577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.1993.tb02550.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1111\/j.1440-1827.1993.tb02550.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.1993.tb02550.x","archive":["Portico"],"relation":{},"ISSN":["0001-6632","0001-6632"],"issn-type":[{"type":"print","value":"0001-6632"},{"type":"electronic","value":"0001-6632"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}