{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T02:38:34Z","timestamp":1725763114421},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"vor","delay-in-days":4943,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>The relationship between the number of apoptotic cells and the expression of apoptosis\u2010related antigens was examined In 56 cases of non\u2010Hodgkin's lymphomas and in 10 cases of reactive hyperplastic lymph nodes (RHL). Apoptosis was visually quantified by the <jats:italic>in situ<\/jats:italic> end\u2010labeling (ISEL) method, and the expression of Fas, Le<jats:sup>y<\/jats:sup> antigens and bcl\u20102 protein was examined by Immunohistochemistry. The expression of Le<jats:sup>y<\/jats:sup> antigen was observed in germinal centers of RHL and 45% of non\u2010Hodgkin's lymphomas. The apoptotic cell count (AC) in follicular lymphomas was significantly less than that in diffuse lymphomas. The distribution pattern of apoptotic cells In follicular lymphomas was inverse to that in RHL. In follicular lymphomas, AC was lower in follicles than in inter\u2010follicular areas. In contrast, AC was higher in follicles than in Interfollicular areas in RHL. Le<jats:sup>y<\/jats:sup> antigen\u2010positive lymphomas showed a significantly higher AC than the negative cases. The Fas antigen\u2010positive lymphomas showed a higher AC than the negative cases. However, AC in bcl\u20102 protein\u2010positive and negative cases was not significantly different. These results suggest that Le<jats:sup>y<\/jats:sup> and Fas antigens appear to be involved in the apoptotic tendency of tumor cells in non\u2010Hodgkin's lymphomas, whereas bcl\u20102 does not necessarily.<\/jats:p>","DOI":"10.1111\/j.1440-1827.1995.tb03479.x","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T13:07:36Z","timestamp":1229087256000},"page":"422-429","source":"Crossref","is-referenced-by-count":8,"title":["Correlation between the number of apoptotic cells and expression of the apoptosis\u2010related antigens Fas, Le<sup>y<\/sup> and bcl\u20102 protein in non\u2010Hodgkin's lymphomas"],"prefix":"10.1111","volume":"45","author":[{"given":"Mohammad","family":"Aftabuddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Yamadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisaku","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaatsu","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.07.110191.003311"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/356397a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4049\/jimmunol.152.4.1751","article-title":"Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways","volume":"152","author":"Wong GHW","year":"1994","journal-title":"J. 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