{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T15:42:39Z","timestamp":1698507759445},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"vor","delay-in-days":4363,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>A rare case Is presented of a 57\u2010year\u2010old Japanese male wlth synchronous and metachronous multicentric squamous cell carcinomas (SCC) In the upper aerodlgesthre tract. Durlng a 9\u2010year\u2010perlod from the appearance of first primary SCC to autopfky, 14 focl of prlmary SCC and one severe dysplasla developed In wccesalon In the thoraclc esophagus, oral floor, soft palnte, uvula, lingual radix, pirlform recess, hypo\u2010phsrynx, cervlcal esophagus, trachea and lingual body. The patlent dkd of severe bronchopneumonla due to Gram\u2010nsgatlve bacterlal lnfectlon that developed as a result of recurrent nerve paralysls. Human papllloma vlrus and Epsteln\u2010Barr virus, which are risk factors, were not detected by lmmunohlstochemlalry or by the polymerase chaln reaction method. Genetlc analysis revealed the absence of polnt mutations In K\u2010ras codon 12. Heavy consumptlon of alcohol and excesstve smoklng may have been responsible for the mulcentrk carclnogenesls. Thls Is the first case report In the llterature of the development of so many prlmary SCC leslons In the upper aerodlgeuwe tract during such a short period.<\/jats:p>","DOI":"10.1111\/j.1440-1827.1997.tb04437.x","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T14:46:13Z","timestamp":1229093173000},"page":"68-72","source":"Crossref","is-referenced-by-count":4,"title":["Synchronous and metachronous multicentric squamous cell carcinomas in the upper aerodigestive tract"],"prefix":"10.1111","volume":"47","author":[{"given":"Liang","family":"Shan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misa","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Jlng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoharu","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennichi","family":"Kakudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"47","article-title":"Cacarcinogenesis and field canwizatjon: Oral lesions offer first signs. 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