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Of them, 51 were extranodal marginal zone B\u2010cell lymphoma (MALT lymphoma), five were diffuse large B\u2010cell lymphoma (DLBCL), one was peripheral T\u2010cell lymphoma, one was NK\/T cell lymphoma, nasal type, and four were reactive lymphoid hyperplasia. These lymphoma cases showed a favorable clinical course and localized disease, except for the case of NK\/T cell lymphoma, although 19 cases (32.8%) had a recurrence of disease. To clarify the correlation between BCL10 protein expression and API2\u2013MALT1 gene rearrangement, the 51 cases of MALT lymphoma and 5 cases of DLBCL were analyzed by immunohistochemical and RT\u2010PCR methods. Nuclear BCL10 expression was identified in 58% of MALT lymphoma cases, but not in any DLBCL cases. There was no evidence of a correlation between aberrant nuclear BCL10 expression and the clinical parameters examined in the present study. API2\u2013MALT1 transcription was not demonstrated in either the MALT lymphoma cases or the DLBCL cases studied using a multiplex one\u2010tube reverse transcriptase\u2010PCR method. These findings indicate that the nuclear expression of BCL10 is unlikely to correlate with the API2\u2010MALT1 fusion gene in ocular adnexal MALT lymphoma.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01580.x","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T13:02:26Z","timestamp":1104238946000},"page":"16-25","source":"Crossref","is-referenced-by-count":32,"title":["No evidence of a correlation between BCL10 expression and API2\u2010MALT1 gene rearrangement in ocular adnexal MALT lymphoma"],"prefix":"10.1111","volume":"54","author":[{"given":"Akiko","family":"Adachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Tamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kou","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ichinohasama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Itoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98024-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199905000-00006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30764-6"},{"key":"e_1_2_6_5_2","first-page":"139","article-title":"Mucosa\u2010associated lymphoid tissue lymphoma","volume":"36","author":"Isaacson PG","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200111000-00001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/8767"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.12.3885"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64630-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1182\/blood.V74.5.1796.1796","article-title":"Four new recurring translocations in non\u2010Hodgkin lymphoma","volume":"74","author":"Levine EG","year":"1989","journal-title":"Blood"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008202303666"},{"key":"e_1_2_6_14_2","first-page":"3944","article-title":"The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low\u2010grade but not high\u2010grade malignant non\u2010Hodgkin's lymphomas of the mucosa\u2010associated lymphoid tissue (MALT\u2010) type","volume":"57","author":"Ott G","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3601"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65499-5"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","unstructured":"DierlammJ BaensM Stefanova\u2010OuzounovaMet al.Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. 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