{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:16:25Z","timestamp":1760782585139},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,15]],"date-time":"2004-03-15T00:00:00Z","timestamp":1079308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Protein kinase C (PKC) enzymes play a major role in signal transduction and contribute to the regulation of cellular differentiation and proliferation. However, little is known about subtype\u2010specific intracellular expression of PKC in human malignant lymphoma. To characterize the relationship between expression of PKC and B\u2010cell lymphomas based on the different subspecies, we investigated the expression of four subspecies (\u03b1, \u03b2II, \u03b3 and \u03b4) in five cases of reactive lymphoid tissues, 77 cases of human B\u2010cell lymphoma and 17 human lymphoma cell lines. In the reactive lymphoid tissues, PKC\u2003\u03b2II\u2010positive cells were found in the mantle zones and marginal zones, and centroblasts and centrocytes in the germinal centers showed cytoplasmic staining with strong intensity against PKC\u2003\u03b4. The present study is the first report to examine the expression of PKC\u2003\u03b4 in reactive lymphoid tissues. In interfollicular areas, a small number of T\u2010cells were positive for PKC\u2003\u03b1. Protein kinase C \u03b3\u2010positive cells were not found in these lymphoid tissues. Eight cases of Burkitt lymphoma (BL) (8\/10; 80%) showed the overexpression of PKC\u2003\u03b1 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01), but other B\u2010cell lymphoma cases except three cases of diffuse large B\u2010cell lymphoma did not express PKC\u2003\u03b1. In addition, six and eight out of nine BL cell lines expressed the protein and mRNA of PKC\u2003\u03b1, respectively. These results indicate that PKC\u2003\u03b1 was predominantly expressed on BL in comparison with other types of lymphoma. The expression of PKC\u2003\u03b3 was observed in only five cases of BL. The overall survival of PKC\u2003\u03b3\u2010positive BL was significantly better than that of PKC\u2003\u03b3\u2010negative BL (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The expression of PKC\u2003\u03b3 seems to be associated with a better prognosis in the limited number of BL cases in the present study.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01612.x","type":"journal-article","created":{"date-parts":[[2004,3,15]],"date-time":"2004-03-15T10:47:51Z","timestamp":1079347671000},"page":"224-230","source":"Crossref","is-referenced-by-count":21,"title":["Characterization of expression of protein kinase C isozymes in human B\u2010cell lymphoma: Relationship between its expression and 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