{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T15:24:07Z","timestamp":1743780247492},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T00:00:00Z","timestamp":1081900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>An 18\u2010year\u2010old woman with abdominal pain was diagnosed as having splenic cysts by computed tomography scan. She had high serum levels of CA19\u20109 (2886.8\u2003U\/mL; normal value, &lt;35\u2003U\/mL), CA125 (131.1\u2003U\/mL; normal value, &lt;35\u2003U\/mL) and soluble IL\u20102 receptor (1490\u2003U\/mL; normal range, 220\u2013530\u2003U\/mL). The resected spleen weighed 1050\u2003g, was 14\u2003\u00d7\u200328\u2003cm, and had more than 10 macroscopic cysts up to 10.3\u2003\u00d7\u20039.5\u2003cm. There were numerous microscopic cysts in the spleen and several on the splenic capsule. The levels of CA19\u20109 and CA125 in the cyst fluid were 2\u2003165\u2003550\u2003U\/mL and 160\u2003400\u2003U\/mL, respectively. After the surgery, the serum levels of the tumor markers decreased gradually. The inside of the largest cyst was mainly covered by granulation tissue with a focal lining of epithelial cells, and the other macroscopic cysts had stratified squamous epithelium. The microscopic splenic cysts and cysts on the splenic capsule were lined by either attenuated single\u2010layered or multilayered epithelial cells. The lining epithelial cells of these cysts were positive for epithelial membrane antigen and cytokeratins. CA19\u20109 and CA125 were detected in the lining cells of the splenic cysts. In the present case, it is suspected that the splenic cysts were derived from the capsular lining cells that showed migration from the capsule or formed microcysts on the splenic capsule, as in the case of ovarian inclusion cysts.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01630.x","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T08:52:58Z","timestamp":1081932778000},"page":"349-354","source":"Crossref","is-referenced-by-count":5,"title":["Multiple epithelial cysts of the spleen and on the splenic capsule, and high serum levels of CA19\u20109, CA125 and soluble IL\u20102 receptor"],"prefix":"10.1111","volume":"54","author":[{"given":"Takeaki","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeaki","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinichi","family":"Haga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,14]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"506","volume-title":"Atlas of Tumor Pathology.","author":"Warnke RA","year":"1995"},{"key":"e_1_2_5_3_2","first-page":"215","article-title":"Nonparasitic, noncancerous cystic tumors of the spleen","volume":"47","author":"Bostick WL","year":"1949","journal-title":"Arch Pathol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800570312"},{"key":"e_1_2_5_5_2","first-page":"251","article-title":"Epidermoid cyst of the spleen. A report of five cases","volume":"96","author":"Tsakraklides V","year":"1973","journal-title":"Arch Pathol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197803000-00002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198804000-00003"},{"key":"e_1_2_5_8_2","first-page":"916","article-title":"Epidermoid cyst derived from an accessory spleen in the pancreas. A case report with literature survey","volume":"41","author":"Morohoshi T","year":"1991","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308048"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2001.01155.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb01726.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00983.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199609000-00001"},{"key":"e_1_2_5_14_2","first-page":"97","article-title":"Metaplastic mesodermal cyst of the spleen","volume":"37","author":"Cave RH","year":"1971","journal-title":"Am Surg"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/76.5.666"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(01)01178-4"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193502"},{"key":"e_1_2_5_18_2","first-page":"1149","article-title":"Laparoscopic resection of a benign true cyst of the spleen with the harmonic scalpel producing high levels of CA19\u20109 and carcinoembryonic antigen","volume":"64","author":"Sardi A","year":"1998","journal-title":"Am Surg"},{"key":"e_1_2_5_19_2","first-page":"151","article-title":"Benign epithelial cyst of the spleen with high production of carbohydrate antigen 19\u20139","volume":"84","author":"Ishibashi R","year":"1999","journal-title":"Int Surg"},{"key":"e_1_2_5_20_2","first-page":"429","article-title":"A disturbance of the IL\u20102\/IL\u20102 receptor system parallels the activity of multiple myeloma","volume":"84","author":"Vacca A","year":"1991","journal-title":"Clin Exp Immunol"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2004.01630.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2004.01630.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:42:00Z","timestamp":1696873320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2004.01630.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,14]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1440-1827.2004.01630.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2004.01630.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,14]]}}}