{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:38:50Z","timestamp":1787315930475,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T00:00:00Z","timestamp":1084320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Intrabiliary growth of liver metastases from colorectal cancer has rarely been studied. A surgically resected case of a metastatic liver tumor with prominent intrabiliary growth derived \u200afrom \u200arectal \u200acancer \u200ais \u200areported. \u200aThe \u200apatient \u200awas \u200aa 62\u2010year\u2010old man who had received a low anterior resection for rectal cancer in March 2000. He was re\u2010admitted due to obstructive jaundice in January 2003, and was diagnosed with hepatic malignancy in segment II of the liver with an intrabiliary tumor extending from the intrahepatic bile duct of segment II to the common hepatic duct. He underwent a left hepatectomy, a partial resection of segment VI, and an extrahepatic bile duct resection with reconstruction of the biliary tract. In the resected specimen, there were whitish tumors of 3\u2003cm and 1.5\u2003cm in diameter in segments II and VI, respectively, and an intrabiliary tumor originating from the main tumor in segment II extended to the common hepatic duct. Both the liver tumors and the intrabiliary tumor consisted of a well\u2010 to moderately differentiated adenocarcinoma, which showed the same histological features as the rectal cancer. The immunohistochemical findings strongly supported that these tumors, including the intrabiliary growth, were liver metastasis from the rectal cancer. The intrabiliary invasion and growth of metastatic liver tumors has generally been overlooked, notwithstanding their frequently observed biological behavior. The present case is informative, and further investigation into this type of metastatic liver tumor may be warranted.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01636.x","type":"journal-article","created":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T04:09:54Z","timestamp":1084334994000},"page":"440-445","source":"Crossref","is-referenced-by-count":27,"title":["Liver metastasis from rectal cancer with prominent intrabile duct growth"],"prefix":"10.1111","volume":"54","author":[{"given":"Susumu","family":"Takamatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Arii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,12]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"267","article-title":"Icteric type hepatoma","volume":"4","author":"Lin TY","year":"1975","journal-title":"Med Chir Dig"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2144::AID-CNCR2820491026>3.0.CO;2-O"},{"key":"e_1_2_5_4_2","first-page":"570","article-title":"Cholangiocellular carcinoma in the caudate lobe with intraluminal growth in the extrahepatic bile duct","volume":"39","author":"Iyomasa S","year":"1992","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/27.1.18"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310104"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70022-X"},{"key":"e_1_2_5_8_2","first-page":"901","article-title":"The expression of cytokeratins 7, 19, and 20 in primary and metastatic carcinomas of the liver","volume":"9","author":"Maeda T","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_5_9_2","first-page":"33","article-title":"Three deceptive cases of intrahepatic metastases of colorectal origin with endobiliary growth, simulating cholangiocarcinoma. 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