{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:35:50Z","timestamp":1767065750677},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,6,4]],"date-time":"2004-06-04T00:00:00Z","timestamp":1086307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>Most primary gastric lymphomas are of B\u2010cell origin. Fourteen cases of primary gastric non\u2010B, non\u2010Hodgkin lymphomas were studied to evaluate their clinicopathological and immunophenotypic findings. The cases were comprised of 11 men and three women, with a median age of 56.5\u2003years. Most patients underwent surgery either with or without chemotherapy, exhibiting a 5\u2003year survival rate of 57.5%. Morphologically, the neoplastic cells showed various histological features, such as anaplastic large cell lymphoma (ALCL) (<jats:italic>n<\/jats:italic>\u2003=\u20033), peripheral T\u2010cell lymphoma, unspecified, large (<jats:italic>n<\/jats:italic>\u2003=\u20034), medium\u2010sized (<jats:italic>n<\/jats:italic>\u2003=\u20032) and mixed cell (<jats:italic>n<\/jats:italic>\u2003=\u20035). Two cases displayed a non\u2010B, non\u2010T cell phenotype, whereas the remaining cases displayed a T\u2010cell phenotype. Six cases were CD4+, while two were CD8+. The neoplastic cells were CD30+ in 10 cases. TIA\u20101 was positive in six cases. In one case, anaplastic large cell lymphoma kinase (ALK) was identified with immunostaining and chromosomal rearrangement of ALK was detected by fluorescence <jats:italic>in\u2003situ<\/jats:italic> hybridization (FISH). In conclusion, although the mechanism of CD30 expression is unknown, primary gastric non\u2010B, non\u2010Hodgkin lymphomas tend to express CD30. We consider that some of the cases in the present study may be derived from cytotoxic T cells, similar to systemic and cutaneous ALCL, the majority of which exhibit TIA\u20101.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01657.x","type":"journal-article","created":{"date-parts":[[2004,6,4]],"date-time":"2004-06-04T11:26:16Z","timestamp":1086348376000},"page":"503-509","source":"Crossref","is-referenced-by-count":14,"title":["Frequent expression of CD30 antigen in the primary gastric non\u2010B, non\u2010Hodgkin lymphomas"],"prefix":"10.1111","volume":"54","author":[{"given":"Sachiko","family":"Iwamizu\u2010Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyoshi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951015)76:8<1313::AID-CNCR2820760804>3.0.CO;2-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90060-4"},{"key":"e_1_2_6_4_2","first-page":"157","volume-title":"World Health Organization Classification of Tumours. 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