{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:59:59Z","timestamp":1697453999822},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T00:00:00Z","timestamp":1099872000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p> <jats:italic>p53<\/jats:italic> gene mutation is not a frequent event in the tumorigenesis of lymphomas and the expression of p53 protein is independent of <jats:italic>p53<\/jats:italic> gene mutations. The present study aimed to investigate mutations in the <jats:italic>p53<\/jats:italic> gene in a series of extranodal B\u2010cell lymphomas, and its association with p53 protein expression. A total of 52 cases were graded histologically into Grade 1, Grade 2 and Grade 3 tumors and p53 protein expression was detected using immunohistochemistry. Mutations in the <jats:italic>p53<\/jats:italic> gene were analyzed using polymerase chain reaction single\u2010strand conformation polymorphism (PCR\u2010SSCP) and mobility shifts were confirmed by direct sequencing. The tumors comprised 26 (50%) Grade 1, 9 (17%) Grade 2 and 15 (29%) Grade 3. A high proportion of Grade 2 (25%) tumors expressed p53 protein (<jats:italic>P<\/jats:italic>\u2003=\u20030.051) and carried <jats:italic>p53<\/jats:italic> gene mutation (33%) (<jats:italic>P<\/jats:italic>\u2003=\u20030.218). However, p53 protein expression was not associated with <jats:italic>p53<\/jats:italic> gene mutations (<jats:italic>P<\/jats:italic>\u2003=\u20030.057). Transversion mutations (88%) were more frequently detected than transition mutations (12%). The present study revealed that <jats:italic>p53<\/jats:italic> gene mutations and p53 protein expression occurred in higher frequencies in Grade 2 tumors, which may be of pathogenetic importance. The high frequency of transversion mutations may reflect the influence of an etiological agent in the tumorigenesis of mucosa\u2010associated lymphoid tissue (MALT lymphoma).<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01765.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T12:24:36Z","timestamp":1100521476000},"page":"811-818","source":"Crossref","is-referenced-by-count":3,"title":["Higher frequency of <i>p53<\/i> gene mutations in diffuse large B\u2010cell lymphoma with MALT component"],"prefix":"10.1111","volume":"54","author":[{"given":"Yan\u2010Chin","family":"Tai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ai Mary 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