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Histopathological examination of the livers revealed T\u2010cell infiltration into the hepatic sinusoids and portal tracts. The morphology of the infiltrated T cells varied from mature small lymphocytes to malignant lymphoid cells. The liver pathology was classified into four groups on the basis of cellular atypia. Group A and group B showed mature lymphoid cell infiltration; however, only group B had multiple large areas of hepatocellular necrosis. Group C showed atypical lymphoid cell infiltration and in group D malignant lymphoid cell infiltrates were demonstrated. The majority of the antigenic phenotypes of these T\u2010cell infiltrates were CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>\u2013<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>, CD20<jats:sup>\u2013<\/jats:sup>, CD45RO<jats:sup>+<\/jats:sup>, CD56<jats:sup>\u2013<\/jats:sup>, CD57<jats:sup>\u2013<\/jats:sup>, TIA\u20101<jats:sup>+<\/jats:sup> and \u03b2F1<jats:sup>\u2013<\/jats:sup>. Epstein\u2013Barr virus RNA in the nuclei of the infiltrated T cells was recorded in 38.6% of the patients and was more common in groups C and D. Patients in groups B, C and D had a very poor prognosis, median survival was only 1\u2003month, whereas median survival in group A patients was 36\u2003months. Chemotherapy was not effective in improving survival.\u200a Monoclonal\u200a band\/s\u200a of\u200a T\u2010cell\u200a receptors\u200a (TCR)\u200a\u03b2 and\/or \u03b3 gene rearrangements were detected in 88.6% of patients, and DNA\u2010sequence analysis showed high identity to the human TCR germline gene.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01766.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T12:24:36Z","timestamp":1100521476000},"page":"819-829","source":"Crossref","is-referenced-by-count":7,"title":["Hepatic cytotoxic T\u2010cell infiltrates in patients with peripheral T\u2010cell proliferative diseases\/lymphomas: Clinicopathological and molecular analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Winyou","family":"Mitarnun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vannarat","family":"Saechan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supaporn","family":"Suwiwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintana","family":"Pradutkanchana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Takao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10094"},{"key":"e_1_2_6_3_2","first-page":"219","article-title":"Hepatic peripheral T\u2010cell lymphoma: a spectrum of liver pathology and clinical correlation","volume":"80","author":"Mitarnun W","year":"1997","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_4_2","first-page":"461","article-title":"The morphologic and immunologic surface marker study of 229 cases of non\u2010Hodgkin's lymphomas and related leukemia","volume":"90","author":"Lukes RJ","year":"1978","journal-title":"Am J Pathol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80299-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440112"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199304000-00010"},{"key":"e_1_2_6_8_2","first-page":"117A","article-title":"High grade AIL and Epstein\u2013Barr virus infection in 22 cases from Mexico","volume":"7","author":"Navarro\u2010Roman L","year":"1994","journal-title":"Mod Pathol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.2.644"},{"key":"e_1_2_6_10_2","first-page":"10","volume-title":"World Health Organization Classification of Tumours. 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