{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:49:24Z","timestamp":1768445364120,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T00:00:00Z","timestamp":1099872000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>Extremely well\u2010differentiated adenocarcinoma (EWDA) is an unusual\u200a gastric\u200a cancer\u200a that\u200a is\u200a histologically\u200a too\u200a bland\u200a to be diagnosed as malignant neoplasm, particularly using biopsy. EWDA may be a gastric counterpart of \u2018adenoma malignum\u2019 or minimal deviation adenocarcinoma (MDA) in the uterine cervix; however, the clinicopathological features of EWDA remain less apparent than those of MDA. A 60\u2010year\u2010old male was complaining of dysphagia. He had been made aware of a small submucosal tumor in the cardia 2\u2003years before the onset of this symptom. Endoscopic ultrasonographic examination revealed a large cardiac tumor consisting of thickened layers, as observed in Borrmann type IV. Three mucosal biopsies suggested only benign changes\u200a including\u200a adenoma\u200a and\u200a hyperplastic\u200a polyps.\u200a At the fourth biopsy, cytologically bland columnar cells were located in the submucosa along with stromal fibrosis and laminated stones. The possibility that non\u2010neoplastic aberrant pancreas with lithiasis formed the tumor was denied at laparotomy by a frozen section that revealed benign\u2010looking glands invading the diaphragm. Immunohistochemically the cancer glands were positive for CA19\u20109 and human gastric mucin, but not for p53 or MUC2. To our knowledge, this is a previously unknown combination of EWDA and psammomatous calcification in the stomach.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2004.01769.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T12:24:36Z","timestamp":1100521476000},"page":"854-860","source":"Crossref","is-referenced-by-count":10,"title":["Extremely well\u2010differentiated adenocarcinoma of the gastric cardia: A unique case with columnar cells and laminated stones"],"prefix":"10.1111","volume":"54","author":[{"given":"Mitsuhiro","family":"Nokubi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kawanowa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Kawata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Hanatsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Hosoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1309\/NYA1-V9KQ-NVF8-MA8M"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90144-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198909000-00001"},{"key":"e_1_2_5_5_2","volume-title":"Tumors of the Cervix, Vagina, and Vulva. Atlas of Tumor Pathology.","author":"Kurman RJ","year":"1992"},{"key":"e_1_2_5_6_2","first-page":"1366","article-title":"A case of gastric cancer with unusual histologic findings","volume":"2","author":"Araki K","year":"1984","journal-title":"Byori to Rinsho"},{"key":"e_1_2_5_7_2","first-page":"211","article-title":"Highly differentiated adenocarcinoma of the stomach. Report of a case with difficulty in pathologic diagnosis on biopsy","volume":"22","author":"Satoh O","year":"1987","journal-title":"I To Cho"},{"key":"e_1_2_5_8_2","first-page":"81","article-title":"Extremely well differentiated adenocarcinoma of the stomach causing difficulty in preoperative diagnosis. Report of a case","volume":"24","author":"Yaosaka T","year":"1989","journal-title":"I To Cho"},{"key":"e_1_2_5_9_2","first-page":"1104","article-title":"An extremely well differentiated gastric adenocarcinoma. A case report","volume":"37","author":"Ueyama T","year":"1991","journal-title":"Gan No Rinsho"},{"key":"e_1_2_5_10_2","first-page":"1531","article-title":"Advanced gastric carcinoma with submucosal growth and low\u2010grade histologic atypia with difficulty in pathological diagnosis by biopsy specimens. Report of a case","volume":"34","author":"Kobayashi M","year":"1999","journal-title":"I To Cho"},{"key":"e_1_2_5_11_2","first-page":"347","article-title":"Heterotopic gastric glands in the submucosa of the stomach","volume":"29","author":"Yamagiwa H","year":"1979","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200301000-00015"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1974.01360060032010"},{"key":"e_1_2_5_14_2","first-page":"975","article-title":"Heterotopic ossification and psammomatous calcification in gastric carcinoma","volume":"29","author":"Imai T","year":"1979","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_5_15_2","first-page":"1261","article-title":"Histopathological studies on gastric carcinomas with calcification","volume":"19","author":"Matsuki K","year":"1984","journal-title":"I To Cho"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01625.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.1.67"},{"key":"e_1_2_5_19_2","first-page":"264","article-title":"Neoplastic Paneth cells in adenocarcinoma of the stomach. A case report","volume":"39","author":"Caruso RA","year":"1992","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_20_2","first-page":"129","article-title":"Neoplastic Paneth cells in the stomach","volume":"113","author":"Lev R","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(93)90062-4"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2004.01769.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2004.01769.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:23:35Z","timestamp":1696872215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2004.01769.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1440-1827.2004.01769.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2004.01769.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}