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In the pyloric region, the relative expression of gastric endocrine cell markers, such as gastrin and somatostatin, decreased gradually from glandular ducts with only gastric mucous cell phenotype (G type) to GI\u2010IM toward I\u2010IM, while that of the intestinal endocrine cell markers, glicentin, gastric inhibitory polypeptide (GIP), and glucagon\u2010like peptide\u20101 (GLP\u20101) was inversely correlated. In the fundic region, gastrin\u2010positive\u200a cells\u200a emerged\u200a in\u200a the\u200a pseudo\u2010pyloric\u200a and\u200a GI\u2010IM glands, whereas I\u2010IM glands did not possess any gastrin\u2010positive cells, suggesting the presence of a distinct pathway of intestinalization. Double staining revealed coexistence of gastrin\u2010 and GLP\u20101\u2010positive cells in the same gland and occasionally in the same cell in GI\u2010IM glands. These results suggest that the phenotypes of endocrine cells are in line with those for mucous counterparts and support the concept that all of the different types of mucous and endocrine cells in normal and IM glands might be derived from a single progenitor cell in each gland.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2005.01809.x","type":"journal-article","created":{"date-parts":[[2005,3,31]],"date-time":"2005-03-31T15:51:56Z","timestamp":1112284316000},"page":"170-179","source":"Crossref","is-referenced-by-count":16,"title":["Coexistence of gastric\u2010 and intestinal\u2010type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach"],"prefix":"10.1111","volume":"55","author":[{"given":"Takafumi","family":"Otsuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Mizoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sosuke","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masae","family":"Tatematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247464"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0950-3528(95)90043-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1955.35"},{"key":"e_1_2_6_5_2","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process. 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