{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:24:44Z","timestamp":1777976684962,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,9,5]],"date-time":"2005-09-05T00:00:00Z","timestamp":1125878400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>The incidence of thyroid involvement by metastatic disease from distant organs ranges from an average of 3.1% in surgical series to 5.3% in autopsy series. However, the metastasis of one tumor into another (traditionally referred to as \u2018tumor\u2010to\u2010tumor metastasis\u2019) is distinctly uncommon. Typically, they are identified as new manifestations or necropsy findings of a known, pre\u2010existing donor tumor. Herein is described the case of a 59\u2010year\u2010old woman whose thyroid nodule (a follicular adenoma) was resected and found to contain foci of a well\u2010differentiated adenocarcinoma with a morphologic and immunohistochemical profile consistent with origination from the lower gastrointestinal tract. Subsequent diagnostic work\u2010up revealed a sigmoid colon tumor with metastases to the liver. This is, to the authors\u2019 knowledge, the first reported example of a colon adenocarcinoma whose initial clinical manifestation was\u200a a metastasis to a thyroid neoplasm and only the third reported example of a colonic adenocarcinoma metastatic to a thyroid tumor. In a review of previously reported examples of tumor\u2010to\u2010tumor metastases involving a thyroid neoplasm as the recipient, the following features were present in the majority: (i) multifocality of the metastatic tumor aggregates; (ii) a total lack of, or only minimal amounts\u200a of reaction (desmoplastic, inflammatory or myxoid) of the recipient tumor to the metastatic deposits; and (iii) retention of the histopathologic characteristics of the donor tumor in the metastatic deposits. In general, strikingly divergent morphologic features in an otherwise typical thyroid neoplasm should elicit a differential diagnosis that takes into consideration the possibility of metastasis.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2005.01871.x","type":"journal-article","created":{"date-parts":[[2005,9,5]],"date-time":"2005-09-05T14:59:31Z","timestamp":1125932371000},"page":"574-579","source":"Crossref","is-referenced-by-count":40,"title":["Tumor\u2010to\u2010tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma"],"prefix":"10.1111","volume":"55","author":[{"given":"Oluwole","family":"Fadare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinita","family":"Parkash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam B.","family":"Mayerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolanle","family":"Asiyanbola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O"},{"key":"e_1_2_6_3_2","first-page":"135","article-title":"Neoplasm to neoplasm metastasis. 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