{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:04:11Z","timestamp":1761487451203},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,9,5]],"date-time":"2005-09-05T00:00:00Z","timestamp":1125878400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>Bronchioloalveolar carcinoma is a distinctive subtype of pulmonary adenocarcinoma, without effective therapy, although there have recently been some attempts to use lung transplantation. However, a high post\u2010transplantation local recurrence rate is described with some controversy regarding the possible involved mechanisms, the main possibilities being the lymphatic spread and aerosolization. Presented herein is a case of a bilateral lung transplantation for a bilateral and pneumonic form of non\u2010mucinous bronchioloalveolar carcinoma in a 43\u2010year\u2010old woman. The histological analysis of mediastinal lymph nodes during surgery did not show neoplastic cells. Thirty\u2010five\u2003months after transplantation several nodular opacities in donor lungs were detected. Three pulmonary wedge resections were performed showing a non\u2010mucinous bronchioloalveolar carcinoma with the same histological characteristics as the primary. Again, the mediastinal lymph nodes were tumor free. A complete microsatellites molecular analysis was performed to compare the primary and recurrent carcinoma using capillary electrophoresis, showing that the recurrent tumor was generated in a recipient cellular clone. The absence of lymph node metastasis and the molecular evidence of the recipient origin of the neoplasm supports the contamination of the new lungs at the time of implantation as being the reason for the high incidence of recurrence after lung transplantation in this kind of disease.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2005.01872.x","type":"journal-article","created":{"date-parts":[[2005,9,5]],"date-time":"2005-09-05T14:59:31Z","timestamp":1125932371000},"page":"580-584","source":"Crossref","is-referenced-by-count":20,"title":["Recurrence of bronchioloalveolar carcinoma in donor lung after lung transplantation: Microsatellite analysis demonstrates a recipient origin"],"prefix":"10.1111","volume":"55","author":[{"given":"J. Javier","family":"G\u00f3mez\u2010Rom\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara Esparza","family":"Del Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Teresa","family":"Zarrabeitia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Cifri\u00e1n","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Zurbano","family":"Go\u00f1i","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Mons","family":"Lera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Cuevas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Fernando","family":"Val\u2010Bernal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,5]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"36","volume-title":"WHO International Histological Classification of Tumours","author":"Travis WD","year":"1999"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200006150-00041"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-200404000-00003"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2003.72"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904083401403"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.5.1423"},{"key":"e_1_2_7_8_2","first-page":"633","article-title":"The multifocallity of bronchioloalveolar lung carcinoma: Evidence and implications of a multiclonal origin","volume":"7","author":"Barsky SH","year":"1994","journal-title":"Mod Pathol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199811000-00004"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000055301"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.1.75"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2005.01872.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2005.01872.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:49:56Z","timestamp":1696949396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2005.01872.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1440-1827.2005.01872.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2005.01872.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}