{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:59:05Z","timestamp":1778126345393,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T00:00:00Z","timestamp":1127692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>The development of de\u2003novo autoimmune liver disease after liver transplantation (LT) has been described in both children and adults. Reported herein is a case that is best characterized as post\u2010LT de\u2003novo hepatitis with features of autoimmune hepatitis (AIH)\u2013primary biliary cirrhosis (PBC) overlap. A 56\u2010year\u2010old man underwent LT for decompensated liver disease secondary to non\u2010alcoholic steatohepatitis. His liver function tests became markedly abnormal 8\u2003months after LT. Sequential liver transplant biopsy findings were confusing and shared findings seen with both AIH and PBC. Although standard autoimmune serological tests were negative, a dramatic biochemical response was observed to a regimen consisting of prednisone, mycophenolate mofetil, and ursodeoxycholic acid added to maintainance tacrolimus. The donor was histocompatibility leukocyte antigen, DR4, positive, a haplotype associated with the development of AIH\u2013PBC overlap syndrome. In conclusion the authors believe that this may be a case of post\u2010LT de\u2003novo overlap syndrome of AIH\u2010PBC, a novel \u2018autoimmune\u2010type\u2019 response.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2005.01886.x","type":"journal-article","created":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T10:05:11Z","timestamp":1127729111000},"page":"660-664","source":"Crossref","is-referenced-by-count":15,"title":["Post\u2010liver transplantation de\u2003novo hepatitis with overlap features"],"prefix":"10.1111","volume":"55","author":[{"given":"Andrew P.","family":"Keaveny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredric D.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urmila","family":"Khettry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.33485"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06478-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199804270-00011"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26756"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31167"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5984"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0016-5085(76)80453-2","article-title":"Responses to treatment can differentiate chronic active liver disease with cholangitic features from primary biliary cirrhosis","volume":"71","author":"Geubel AP","year":"1976","journal-title":"Gastroenterology"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290409"},{"key":"e_1_2_5_10_2","first-page":"363","volume-title":"Liver Immunology","author":"Beuers U","year":"2003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.23792"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.36392"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb01321.x"},{"key":"e_1_2_5_14_2","first-page":"371","volume-title":"Transplantation of the Liver","author":"Faust TW","year":"2001"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199511000-00008"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065530"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180103"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200103150-00016"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1827.2005.01886.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1827.2005.01886.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:03:55Z","timestamp":1696928635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1827.2005.01886.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,26]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1111\/j.1440-1827.2005.01886.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1827.2005.01886.x","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,26]]}}}