{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:25:06Z","timestamp":1792445106767,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T00:00:00Z","timestamp":1130198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>CD117 (KIT) is expressed in a variety of hematopoietic neoplasms but there are a paucity of data regarding its expression in diffuse large B\u2010cell lymphomas (DLBCL). The purpose of the present paper was to describe the authors\u2019 experience of two CD117+ DLBCL (one of follicle center\u2010cell origin and one nasal Epstein\u2013Barr virus (EBV)\u2013 plasmablastic lymphoma associated with lytic bone lesions), as determined by tissue immunohistochemistry and flow cytometry. The CD117 expression in DLBCL was further evaluated using tissue microarrays and seven additional plasmablastic lymphomas, using two commercially available anti\u2010CD117 antibodies (Ab\u20101, Oncogene and A4502, DakoCytomation). Membranous\u2003\u00b1\u2003cytoplasmic staining was seen with Ab\u20101 in 24\/65 (37%) DLBCL, including 21\/56 microarray DLBCL, two index cases, and 1\/7 additional plasmablastic lymphomas, with persistent staining in 13% of microarray DLBCL despite preincubation with KIT peptide. However, A4502 had only membranous staining of the index cases and one additional EBV\u2013 plasmablastic lymphoma with medullary disease. The present study suggests that (i) CD117 expression can be detected sporadically in DLBCL of follicle center\u2010cell origin and a subset of plasmablastic lymphomas; (ii) staining for CD117 might help in identifying EBV\u2013 plasmablastic lymphomas associated with bone marrow involvement; and (iii) CD117 antibodies should be carefully validated prior to use, because non\u2010specific staining, as observed with Ab\u20101, could lead to false\u2010positive results.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2005.01893.x","type":"journal-article","created":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T07:59:24Z","timestamp":1130227164000},"page":"716-723","source":"Crossref","is-referenced-by-count":13,"title":["CD117 expression in diffuse large B\u2010cell lymphomas: Fact or 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