{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:17:03Z","timestamp":1763641023340},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T00:00:00Z","timestamp":1138579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>Adenoid squamous cell carcinoma (ASCC) is an uncommon but well\u2010recognized variant of squamous cell carcinoma that was first described by Lever in 1947. ASCC has been reported to originate in the sun\u2010exposed skin of the head and neck and in other sites. An additional case of ASCC is reported here. The patient was a 64\u2010year\u2010old Japanese woman who requested examination of a reddish lesion on the left floor of the mouth. The biopsy material was diagnosed as squamous cell carcinoma. Clinical examination showed a well\u2010circumscribed, 20\u2003\u00d7\u200310\u2003mm\u2010sized lesion, which was categorized as cT2cN0c<jats:sc>m<\/jats:sc> 0. Tumor resection was therefore performed. Histologically, most parts of the lesion were conventional squamous cell carcinoma <jats:italic>in situ<\/jats:italic>, but the invasive part consisted of ASCC with gland\u2010like or reticular appearance. The latter part was negative for mucin staining. Immunohistochemically, this lesion was positive for pancytokeratin, high\u2010molecular\u2010weight keratin, cytokeratin (CK) 7\/8, CK19, E\u2010cadherin and p53, but negative for vimentin, CK20, and S\u2010100 protein. The Ki\u201067 labeling index was 50.3% in the ASCC part and 34.5% in the carcinoma <jats:italic>in situ<\/jats:italic> part. These findings and a review of the literature indicate that a gland\u2010like feature of ASCC is associated with the loss of cell adhesion in the center of the cancer nests, and it can be confirmed simply by mucin staining to be neither an adenosquamous carcinoma nor ductal involvement of conventional squamous cell carcinoma.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.01927.x","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T09:24:17Z","timestamp":1138613057000},"page":"78-83","source":"Crossref","is-referenced-by-count":21,"title":["Primary adenoid squamous cell carcinoma of the oral 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