{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:54:14Z","timestamp":1765040054142},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Mantle cell lymphoma (MCL) is a rare B\u2010cell lymphoma that has never been characterized in Taiwan. The purpose of the present paper was to retrospectively identify 21 cases in male patients, with a median age of 61, involving lymph node (91%), marrow (71%), and peripheral blood (23%). Eighteen (86%) were in stages III\/IV with 1 and 5\u2003year survival rates of 78% and 17%, respectively. Mixed nodular and diffuse pattern (45%) was most common while interstitial pattern (92%) predominated in marrow. Eighteen (86%) were of classical morphology, two were pleomorphic and one was blastic. The tumors expressed IgM and bcl\u20102 (100%), cyclin D1 (95%), CD5 (86%), CD43 and IgD (62%), CD52 (60%), and bcl\u20106 (5%). Ki\u201067 index \u226530% (<jats:italic>P<\/jats:italic>\u2003=\u20030.1834) was associated with a trend toward poorer survival while p21, p27, or p53 expression was not statistically significant for survival. Real\u2010time polymerase chain reaction for <jats:italic>cyclin D1<\/jats:italic> (<jats:italic>CCND1<\/jats:italic>) gene mRNA expression showed high levels in nine cyclin D1\u2010positive patients and a low level in the single cyclin D1\u2010negative patient. The latter patient was cyclin D2 positive and negative for <jats:italic>immunoglubuin heavy chain<\/jats:italic> gene and <jats:italic>CCND1<\/jats:italic> gene translocation by locus\u2010specific interphase fluorescent <jats:italic>in situ<\/jats:italic> hybridization. In conclusion, it is confirmed that the usual morphological variants and aberrant immunophenotype of MCL in the West occur in Taiwan and that this disease carries a poor prognosis.<\/jats:p>","DOI":"10.1111\/j.1440-1827.2006.01986.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T08:58:46Z","timestamp":1152694726000},"page":"440-448","source":"Crossref","is-referenced-by-count":17,"title":["Mantle cell lymphoma in Taiwan: Clinicopathological and molecular study of 21 cases including one cyclin D1\u2010negative tumor expressing cyclin 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